lecture 21: neuromuscular disorders

Question 1

direct neuromusclular disorders

Answer 1

pathologies of voluntary muscle

Question 2

indirect neuromuscular disorders

Answer 2

pathologies of nerves or NMJ

Question 3

4 types of disorder which involve damage to:

Answer 3

1. lower motor neurons
2. peripheral nerves
3. NMJ
4. muscle

Question 4

1. lower motor neurons

Answer 4

• rare
• males over 50
• 3yr survival
• bulbar muscle palsy
• sensory system not involved
• riluzole (glutamate inhibitor)

Question 5

2. peripheral nerves

Answer 5

• neuropathy
• mononeuropathy (CTS)
• mononeuritis multiplex e.g. vasculitis
• polyneuropathy e.g. Guillain-Barre syndrome

Question 6

CTS risk factors

Answer 6

• strenuous, repetitive work
• arthritis
• pregnancy
• diabetes
  -obesity
• hand injuries

Question 7

CTS treatment

Answer 7

• wrist splints
• steroid injections
• release surgery

Question 8

3. NMJ

Answer 8

• myasenthia gravis

autoimmune- generate AB against own nicotinic acetylcholine receptors at motor end plate

• diplopia, ptosis

Question 9

MG treatment

Answer 9

• corticosterioids
• immunosupressive drugs
• acetylcholinesterase inhibitors
• AB revoval
• thymectomy

Question 10

4. muscle

Answer 10

DMD
- x linked
- mutation in dystrophin gene
- live up to 30 yrs
- treatment= OT, corticosteroids