Lecture 38: Reproductive System Development Flashcards Preview

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Flashcards in Lecture 38: Reproductive System Development Deck (16):
1

Explain what is meant by the gonads being a "bipotential system".

The gonads are indifferent at the beginning of reproductive development and retain potential to develop ovary or testis

2

What is the "default" condition during reproductive development?

Female

3

What causes the gonad to develop into testis rather than continuing onto the default pathway?

Sry gene on the Y chromosome

4

What forms from the medulla of the indifferent gonad?

Sex cords, which may give rise to seminiferous tubules

5

What forms from the cortex of the indifferent gonad?

Ovary

6

What is the fate of the tunica albugnea in the adult gonad (male and female)?

Male: lies on external surface of testis
Female: internalized in ovary

7

How are the mesonephric tubules related to the developing gonads?

Males: retained and become efferent ductules
Females: usually degenerate

8

What is the fate of the Mullerian ducts after gonad is differentiated into testes?

Testis secrete Mullerian inhibiting substance and Mullerian ducts regress

9

What is the fate of Wolffian ducts after gonad is differentiated into testes?

Testosterone acts on Wolffian (mesonephric) ducts which develop into the ductus deferens

10

What is the fate of the Mullerian ducts after gonad is differentiated into ovary?

Mullerian ducts "passively" develop as this is the default pathway

11

What is the fate of the Wolffian (mesonephric) ducts after gonad is differentiated into ovary?

Mesonephric/Wolffian ducts regress

12

Name the 3 primordia of the external genitalia

Genital tubercle, Genital folds, Genital swellings

13

What does the genital tubercle give rise to in males and females?

Males: plans penis; Females: clitoris

14

What do the genital folds give rise to in males and females?

Males: fuse and form shaft of penis; Females: remain unfused and form labia minora

15

What do the genital swellings give rise to in males and females?

Males: fuse and form scrotum; Females: remain unfused and form labia majora

16

What is the role of Dazl in the differentiation of primordial germ cells?

Dazl allows germ cell to undergo meiosis; without Dazl, individual will be sterile - no meiosis occurring