Lecture 40: Heart Development I Flashcards Preview

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Flashcards in Lecture 40: Heart Development I Deck (13):
1

What forms from the primary heart field (heart crescent)?

Left ventricle, atria

2

What is the most primitive component of the mammalian heart?

Primary heart field/heart crescent

3

How is retinoic acid related to atrial or ventricular identity?

High gradient of RA exposed to cells posteriorly and they assume atrial identity; No RA exposure anteriorly and cells assume ventricular (default) identity

4

What is the result of the absence of Hand-1 expression in the primary heart field?

Defective left ventricle

5

What forms from the secondary heart field?

Right ventricle, proximal outflow tract

6

What is the result of absence of Hand-2 expression in the secondary heart field?

Absence of right ventricle

7

What forms from the proepicardium?

epicardium, interstitial cells, vascular smooth muscle, cornoary vasculature

8

What transcription factor guides formation of primary myocardium from cardiac tube?

Tbx-2

9

What transcription factor guides formation of the chamber myocardium?

Tbx-5

10

What are the results of cardiac looping?

S-shaped heart, atrium becomes dorsal to outflow part of heart, internal septa divide ventricle, then atrium

11

Bulbus cordis

Outflow part of the heart that leads to aortic sac and aortic arch system

12

Name the broader, proximal part of the bulbus cordis

Conus arteriosus

13

Name the narrower, distal part of the bulbus cordis

Truncus arteriosus