Lecture 9: Developmental Genetics I Flashcards Preview

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Flashcards in Lecture 9: Developmental Genetics I Deck (10):
1

Homeobox

contain highly conserved sequence of 180 nucleotides coding for a 60 amino acid homeodomain

2

In which direction are homeobox containing genes activated?

3' to 5' direction (opposite of transcription)

3

What is the result of a loss-of-function mutation in homeobox genes?

Posterior to anterior transformations

4

What is the result of a gain-of-function mutation in homeobox genes?

Anterior to posterior transformations

5

T-box genes (Tbx)

Contain conserved T-box coding 180-200 amino acids; plays role in inducing mesodermal germ layer and coordinating limb development

6

Helix-loop-helix genes

Code for basic helix-hoop-helix transcription factors; involved in homo/heterodimerization, important in myogenesis

7

Forkhead (Fox) genes

Type of helix-loop-helix family expressed in many developing organs throughout the body

8

Zinc finger transcription factors

Contain zinc ions bound to polypeptide chain causing chain to form finger-like projections inserted into DNA helix. Gene families = Sox, WT1

9

Sox genes

High-mobility group domain binding to minor groove on DNA helix, including SRY gene

10

WT1 gene

Important for development of embryonic kidney and adult kidney