Flashcards in Lecture 9: Developmental Genetics I Deck (10):
contain highly conserved sequence of 180 nucleotides coding for a 60 amino acid homeodomain
In which direction are homeobox containing genes activated?
3' to 5' direction (opposite of transcription)
What is the result of a loss-of-function mutation in homeobox genes?
Posterior to anterior transformations
What is the result of a gain-of-function mutation in homeobox genes?
Anterior to posterior transformations
T-box genes (Tbx)
Contain conserved T-box coding 180-200 amino acids; plays role in inducing mesodermal germ layer and coordinating limb development
Code for basic helix-hoop-helix transcription factors; involved in homo/heterodimerization, important in myogenesis
Forkhead (Fox) genes
Type of helix-loop-helix family expressed in many developing organs throughout the body
Zinc finger transcription factors
Contain zinc ions bound to polypeptide chain causing chain to form finger-like projections inserted into DNA helix. Gene families = Sox, WT1
High-mobility group domain binding to minor groove on DNA helix, including SRY gene