Lecture 5 Flashcards
(39 cards)
Connective Tissue?
Tissue (cells + fibers) that supports, protects and gives structure to other tissues and organs in the body
What is CT made of?
-4 different types of cells (Fibroblast, Macrophage, Mast Cell, and Plasma Cell)
-3 different types of fibers (Collagen (Type IV), Elastin, and Reticular (Type III Collagen))
4 Different Types of Cells that make up CT?
-Fibroblast
-Macrophage
-Mast Cell
-Plasma Cell
Fibroblast?
Produces collagen fibers (ex. it is the main cell producing ECM fibers)
Macrophage?
Immune Cell
Mast Cell?
Immune Cell –> produces response to allergic reaction
Plasma Cell?
Immune Cell –> produces antibodies
3 Different Types of Fibers that make up CT?
-Collagen (Type IV)
-Elastin
-Reticular (Type III Collagen) –> stains with silver (metal) (produced by reticulocytes)
Cells + ECM (fibers + ground substance) = ?
CT
The Major Cellular Component of CT?
Fibroblasts
Fibroblasts produces?
Collagen Fibers (ex. other major component of CT) (but can also produce elastic fibers that do NOT contain any collagen)
Characteristics of Fibroblasts (under LM)?
-Stain= dark purple with H-stain (because they have rER + ribosomes)
-Cell= spindle-shaped
-Nuclei= flat; cigar-shaped
Immune Cells?
-Macrophages
-Mast Cells
-Plasma Cells
Immune Cells?
-Macrophages
-Mast Cells
-Plasma Cells
Macrophages?
-Phagocytic –> have lysosomes to digest material
-Stain= purple (H-stain)
-Cell= irregular shape
-Cytoplasm= vacuoles appear as “open spaces”
-Nuclei= large, irregularly-shaped
Mast Cells?
-Degranulation –> leads to allergic response
-2 Locations (mucosa and adult CT)
-Stain= purple (H-stain)
-Cell= round/oval shape
-Cytoplasm= many dark purple granules
-Nuclei= tightly-stained round shape
Which 2 Locations are Mast Cells located at?
-Mucosa (loose CT= lamina propria)
-Adult CT (CT proper)
Plasma Cells?
-B-lymphocytes exposed to Ag –> produces Abs
-Stain= purple (H-stain) with small pale area near nucleus
-Cytoplasm= purple staining due to lots of rER
-Nuclei= large, eccentric (off-center), cartwheel appearance
Plasma Cells?
-B-lymphocytes exposed to Ag –> produces Abs
-Stain= purple (H-stain) with small pale area near nucleus
-Cytoplasm= purple staining due to lots of rER
-Nuclei= large, eccentric (off-center), cartwheel appearance
Extracellular Matrix?
A gelatinous blend of water + ions + collagen + glycoprotein + proteoglycan
ECM surrounds?
Cells and fibers of CT for support, metabolism + cell communication
Glycosaminoglycans?
(GAGs)
-Exist as proteins complex with polysaccharides
-Function= control linkages between ECM components
-Make up major component of PG aggregates
Function of Glycosaminoglycans?
Control linkages between ECM components
GAGs + PGs + glycoproteins = ?
Ground Substance of ECM
