Leprosy/Lyme Dz

Question 1

Mycobacterium Leprae

Answer 1

Leprosy; low virulence
tropical areas 
genetics may play a role in xsmission
children more susceptible
CANNOT be cultured 
AF staining of scrapings --> lepra cells
Tx with Dapsone

Question 2

Tuberculoid leprosy

Answer 2

benign, non-progressive
lesion have few AFB
peripheral nerve damage and sensory loss
\+ lepromin (DTH) test
intact CMI
Th1 cells in skin

Question 3

Lepromatous leprosy

Answer 3

malignant, progressive
nodular skin lesions with LOTS of AFB
Lepromin test -
Th2 activation (wrong type)

Question 4

Borrelia Burgdorferi

Answer 4

spirochete visualized by dark field micro
xsmit by Ixodes flea
surface antigens OspA and OspB
fastidious at 33deg
patho due to BYSTANDER injury to host

Question 5

Borrelia spp

Answer 5

Relapsing fever
soft bodied ticks or human louse
epidemic form not in US
endemic form in Western US
antigenic variation
fever coincides with organ in blood