Lesson 4 Flashcards
(16 cards)
Innate Immunity Targets….
microbes
Adaptive Immunity Targets…
antigens
Neutrophils
SEGs
phagocytosis, inflammation, and debridement
first at site of infection
self destruct after
Monocyte
Macrophages
Phagocytosis, antigen presentation
make cytokines
NK Cells
kill virus infected and altered self cells
Eosinophils
kill parasites
allergies
Microbial Molecular Patterns
Lipopolysaccharides- TLR4
Flagellin- TLR3
dsRNA- TLR3
Unmethylated CpG dinucleotides
Pathogen Associated Molecular Patterns
PAMP
microbe associated
Pattern Recognition Receptors
PRR
Phagocyte associated
IL-1
increase adhesion factor expression
act on hypothalamus
Toll Like Receptor
bind to, ingest, kill microbes
require ROS and NO
How does a macrophage or neutrophil kill yeast?
oxidative burst
3 Complement Pathways
Alternative- innate
Lectin- innate
Classical- adaptive
C- Reactive Protein
CRP
blood biomarker of inflammation
Similarities b/t TNF-a and IL-6
Pro- inflammatory
cause fever
Differences b/t TNF-a and IL-6
TNF causes shock
IL causes acute phase proteins to be produced
