Tolerance and Autoimmunology Flashcards Preview

Immunology > Tolerance and Autoimmunology > Flashcards

Flashcards in Tolerance and Autoimmunology Deck (19)
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1
Q

Tolerance

A

specific non-response triggered by previous exposure to specific antigen
recognized by lymphocytes
in B and T cells

2
Q

Tolerogens

A

antigens that induce tolerance

3
Q

Self Tolerance

A

tolerant of self antigens

4
Q

Antigen Inductions

A

foreign Ag administered in ways that inhibit immune response by inducing tolerance in specific lymphocytes

5
Q

Immunodeficiency

A

deficiency or inability to have humoral or cell mediated immune response
lacks specificity to antigen

6
Q

Immunosuppression

A

suppression of immune responses to Ag due to physical or chemical change
lacks specificity to Ag

7
Q

Antigen Factors

A

Antigen dose
physical form- monomer, aggregates
route of admission

8
Q

Dose of Antigen

Favoring Immune Response vs Tolerance

A

Optimal Dose

Very large or very small dose

9
Q

Physical Form of Ag

Favoring Immune Response vs Tolerance

A

large, aggregated, complex, processed molecules

soluble, aggregate free, simple, NOT processed mol

10
Q

Administration Route

Favoring Immune Response vs Tolerance

A

Subcutaneous or intramuscular

Oral or intravenous

11
Q

Age

Favoring Immune Response vs Tolerance

A

Adult- mature T and B cells

Newborn- immunologically immature

12
Q

Central Tolerance

A

in central lymphoid organs as result of immature self reactive lymphocytes recognizing self Ag
Thymus and Bone Marrow

13
Q

Peripheral Tolerance

A

in peripheral organs as a result of mature self reactive lymphocytes recognizing tissue specific self Ag

14
Q

Clonal Deletion

A

deletion of T cells that have receptors specific for self Ag
by negative selection
results in self tolerance

15
Q

Clonal Anergy

A

lack of co-stimulatory signals

action of regulatory lymphocytes via IL10

16
Q

Autoimmunity

A

failure to control function of self reactive cells

cause autoimmune disease

17
Q

Autoimmunity

A

pathology as a result of immune response to self

18
Q

Hashimoto’s Thyroiditis

A

hypothyroidism

destroys cells

19
Q

Graves Disease

A

hyperthyroidism

activates TSH receptor