MHC Flashcards
(21 cards)
Human Leukocyte Antigen
serum of women containing Ab that agglutinate husband’s leukocytes
responsible for tissue transplant rejection
now MHC
Major Histocompatibility Complex
reject tissue transplant- core to self tolerance
key to normal immune response
present epitopes to TCR
polymorphic and polygenic
MHC-1 consist of…
all nucleated cells
MHC-2 consist of…
B-cells and APCs
Tc/ CD-8
recognize peptides bound to MHC-1
Th/ CD-4
recognize peptides bound to MHC-2
Major Loci of MHC-1
A, B, C
Major Loci of MHC-2
DP, DQ, DR
Endogenous Antigens
from w/in cell- not phagocytized
presented by MHC-1 to CD-8
Exogenous Antigens
from outside cell- phagocytized
presented by MHC-2 to CD-4
MHC-1 Structure
a3 docks CD-8
a1 and a2 bind Ag
MHC-2 Structure
a1 and B1 bind Ag
B2 docks CD4
Antigenicity
capacity to stim antibody production
Epitope
portion of antigen bound by antibody or T cell receptor
Hapten
substance capable of reacting w/ specific Ab but cannot induce formation of Ab unless bound to carrier protein
Lysosomes
phagocytize and digest Ag
T-Cell Receptor
has a and B chain that allows it to bind to Ag presented by MHC-1 and 2
CD3
required for TCR development and function
in signal transduction after activation
Signals Required for T-Cell Activation
Engagement of TCR w/ MHC:Ag
Engagement of costimulatory molecules w/ ligand
Th1
promote cell mediated response
differentiate Tc and NK
Th2
promote Ab mediated response
drive B cell activation and differentiation
release IL4 and IL10
