Lewis Part 2

Question 1

CANNOT CAUSE______

Le antibodies are____ (cannot cross through placenta)

Le antigens are not fully developed at birth

It will only be develop____ after birth

Answer 1

HDFN

IgM

10 days

Question 2

• CONSIDERED INSIGNIFICANT IN BLOOD TRANSFUSION

_______can be easily neutralized by Le antigen in plasma

IMPORTANT: detects @ 37°C and Coombs phase (+)

Answer 2

Le antibody

Question 3

can readily dissociate from RBCS (not permanent on RBC)

Answer 3

Le antigen

Question 4

OTHER LEWIS ANTIGENS

Le Se^w→
“W” - means weak

Answer 4

Le(a+b+)

Question 5

analogous to Le^a

analogous to Le^b

Answer 5

• Le^c

• Le^d

Question 6

isomer of Le^a

isomer of Le^b

Answer 6

• Le^x

• Le^y

Question 7

are molecules with the same formula but different structures.

Answer 7

Isomers

Question 8

compounds have different structures but similar properties because of similar functional groups.

Answer 8

Analogous

Question 9

SECRETION

Le(a+b-)

Nonsecretors

Nonsecretor b/c its structure is paragloboside w/ no glucose attached

Answer 9

Le^c

Question 10

SECRETION

Le(a-b+)
Secretors
Secretor b/c it is similar to H antigen

Answer 10

Led

Question 11

Le^x

Secretion

Answer 11

Le^a

Question 12

Le^y

Secretion

Answer 12

Le^b

Question 13

If you have Le^c in secretions→ in RBC…

Answer 13

you’re nonsecretor in RBC
Le(a-b-)

Question 14

If you have Le^d in secretions→in RBC…

Answer 14

you’re secretor in RBC Le(a-b-)

Question 15

• If you have Le^a in secretions→ possibly, when adsorbed by RBC produces…

Answer 15

Le^x

Question 16

• If you have Le^b in secretions→possibly, when adsorbed by RBC produces…

Answer 16

Le^y

Question 17

Lewis null and/or non secretor phenotype has also been linked w/ a higher incidence of recurrent…

Answer 17

Candida vaginitis & UTI

Question 18

Nonsecretor phenotype protects against…

Answer 18

Norovirus infection

Question 19

binds to H, Le^b & Le^y antigens

Answer 19

Helicobacter pylori

Question 20

1. SECRETIONS
   •_________
   • CANNOT adsorb onto RBC
   membranes

Answer 20

GLYCOPROTEINS

Question 21

2. PLASMA
   •________ (mostly produced in GIT)
   CAN adsorb onto RBC
   membranes

Answer 21

GLYCOLIPIDS

Question 22

LEWIS ANTIGEN
If the Le gene is inherited, ____ substance is produced

Le and Se gene must be inherited to convert H to ____

Answer 22

Le^a
Le^b

Question 23

Le se H →
Le Se H →
le se H →
le Se H →

Answer 23

Le (a+b-)

Le (a-b+)

Le (a-b-) → H antigen

Le (a-b-) → H antigen

Question 24

“w” Stands for weak
Formation of non-functional or partially functional transferase

Answer 24

Le^w

Question 25

Le Detectable in the RBCs approximately_____ after birth Lewis glycolipids are not detectable in plasma until _____after birth

Answer 25

10 days 10 days

Question 26

are detectable in saliva at birth

Answer 26

Le^a & Le^b glycoproteins

Question 27

Le - se Newborn: Le (a-b-) ~after 10 days

Answer 27

Le (a+b-)

Question 28

Le - Se Newborn: Le (a-b-) ~after 10 days _______ Le (a+b+) ~after 6 years _______

Answer 28

Le (a+b-) Le (a-b+)

Question 29

le - se all throughout (amorph) Le gene can easily be neutralized

Answer 29

Le (a-b-)

Question 30

REASONS Transformation into Le (a-b-)

Answer 30

Pregnancy Cancer Alcohol cirrhosis Viral infection Parasitic infections

Question 31

Le (a-b-) Transformation into Le (a+b-) or Le (a-b+)

Answer 31

Incubate Le (a-b-) to the PLASMA of Le (a+b-) or Le (a-b+)

Question 32

If patient 1 is Le (a-b-) and the plasma of patient 2 is Le (a+b-). If the plasma of patient 1 has been incubated to the plasma of patient 2, after the incubation the red cell of patient 1 will be_____

Answer 32

Le (a+b-).