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IHBB LEC > Uncommon Blood Groups Prt.1 > Flashcards

Uncommon Blood Groups Prt.1 Flashcards

(53 cards)

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1
Q

DIEGO

Chromosome
Gene

A

• CHROMOSOME 17
• SLC4A1 gene

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2
Q

DIEGO

Antibodies

A

• IgG, sometimes IgM
•Causes HTR and HDFN

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3
Q

DIEGO

• ANTIGENS
•_____ antigens
• High and low prevalence antigens

• Carried on band___
•____ exchanger
• Carries ABH and I antigens

A

22

3

Anion

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4
Q

DIEGO

Expression???
Resistant to??? (4)

A

•Expressed upon birth
• Resistant to ficin, papain, DTT, glycine-acid EDTA

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5
Q

• = first discovered maker of anti-yt

A

Cartwright

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6
Q

YT

• CHROMOSOME___
•____ gene

A

7

AChE

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7
Q

YT

• ANTIBODIES

A

• IgG (1 and 4)
• May cause HTR

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8
Q

YT

• ______= common phenotype
•____ - high incidence
•____ - not found in Japanese - (Israelis)

A

Yt (a+b-)

Yta

Ytb-low

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9
Q

• ANTIGENS
• High and low prevalence antigens
• Developed upon birth
• Negative in PNH cells

A

YT

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10
Q

YT

• Sensitive to (3)
• Resistant to (1)

A

ficin, papain, and DTT

glycine-acid EDTA

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11
Q

Xg

•____chromosomes
•____ and _____genes

A

X

XG and MIC2

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12
Q

Xg

• Antibodies
•____, some are naturally occuring
• Not implicated in HTR and
HDFN

A

IgG

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13
Q

Xg

g for ‘_______’, ‘, the location
where the person was treated

A

Grand Rapids

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14
Q

Xg

Antigens
• (2)
•____% in women and____% in males

A

Xgª and CD99

89

66

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15
Q

Xg

•Sensitive to (2)
• Resistant to___

A

ficin and papain

DTT

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16
Q

Scianna System

CHROMOSOME___

• ______ gene- RBC ahesion CHON

A

1

ERMAP gene (Erythroid
Membrane Associated Protein)

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17
Q

Scianna

• ANTIBODIES
•____
• May cause mild HTR and mild HDFN

A

IgG

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18
Q

Scianna system

ANTIGENS
• _____antigens
• High (5) and low prevalence (2) Ags

A

7

SC1, 3, 5,6,7

SC2, SC4

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19
Q

Scianna

• Carried on_____
• Expressed on____
• Resistant to (2)
• Slightly weakened by ____

A

ERMAP

cord RBCS

ficin and papain

DTT

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20
Q

Dombrock

CHROMOSOME____

•______ gene (regulation of cellular protein function)]

A

12

ART4 gene [monoART4 = mono-ADP-ribosyltransferase 4

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21
Q

Dombrock

• ANTIBODIES
•___ rarely ____
• Causes____ but not ____

A

IgG, rarely IgM

delayed HTR but not HDFN

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22
Q

Dombrock

ANTIGENS
• High and low prevalence Ags •Carried on mono-ART4
•Expressed upon birth: (-) in PNH
cells

• Resistant to (3)
• Sensitive to (1)

Study These Flashcards
A

ficin, papain, glycine-acid EDTA

DTT

23
Q

Dombrock

• High Prevalence Ags:
(2) - (poor immunogens)
____ - (highly immunogenic) and
(4)

Study These Flashcards
A

Doa and Dob

Gya

Hy; Joa; DOYA and DOMR

24
Q

Dombrock

(3)- high incidence antigens

Study These Flashcards
A

• Gya, Hy, Joa

25
Colton • CHROMOSOME____ •____ gene
7 AQP1
26
Colton • ANTIBODIES •___ rarely ___ • Causes_____ and ____
IgG, rarely IgM HTR and HDFN
27
Colton ANTIGENS •____ antigens • High (___) and low prevelance (____) Ags • Carried on____ • Integral protein • Expressed upon birth • Resistant to (4)
4 Coa; Cob aquaporin 1 ficin, papain, DTT, chloroquine
28
Colton Antigens •______ present in all RBCs except with the Co(a-b-) phenotype •_____ present with the Co(a-b-) phenotype
Co3 Co4
29
Landsteiner-Wiener system CHROMOSOME___ •______ gene [intracellular adhesion molecule]
19 ICAM4
30
Landsteiner-Wiener System • ANTIBODIES • Probably___ • HTR/HDFN???
IgM DO NOT CAUSE HTR and HDFN
31
Landsteiner-Wiener ANTIGENS •___ antigens • High (2) prevalence Ags • low prevalence (1) Ags • Carried on_____ • Null phenotype:____
3 Lwa, Lwab LWb ICAM-4 LW(a-b-)
32
Landsteiner-Wiener • Destroyed by____ • Resistant to ____ and ____
DTT enzymes and glycine-acid EDTA
33
• Reacts to all cord cells regardless of o type, one way to differentiate it with anti-Rh
Landsteiner-Wiener
34
Chido/ Rodger • CHROMOSOME___ • ______ and _____ gene
6 C4A (Rg) and C4B gene (Ch)
35
Chido/ Rodgers • ANTIBODIES •____, neutralized by____ • Clinically significant/ insignificant???
IgG plasma insignificant
36
Chido/ Rodgers ANTIGENS •___ antigens • High (8) and low prevalence (1) Ags • Carried what genes???
9 CH1-CH6; RG1, RG2; WH C4A (Rg); C4B (Ch)
37
Chido/ Rodgers • Destroyed by (2) • Resistant to (3)
ficin, papain DTT, glycine-acid EDTA
38
Gerbich CHROMOSOME___ •___ gene
2 GYPC
39
Gerbich Antigens • 6 (high freq) - • 5 (low freq) -
Ge2, Ge3, Ge4, GEPL, GEAT and GEt1 Wb, Lsa, Ana, Dha, GET1
40
Gerbich Antigens • Expressed on ____ and ____ • Expressed at birth • Decreased in_____ • Resistant to (2)
GPC and GPD hereditary elliptocytosis (loss of protein 4.1)
41
Decreased in hereditary elliptocytosis (loss of protein 4.1)
Gerbich
42
Gerbich • NULL/WEAK PHENOTYPES (3)
• Yus (Ge-2, 3,4) • Gerbich (Ge-2, -3, 4) • Leach (Ge-2, -3, -4)
43
Gerbich • ANTIBODIES •_____ (most common) • Mostly IgG, rarely IgM (RT, enhanced by____) • Usually clinically significant • Mrs. Gerbich - first ab producer
Anti-Ge2 AHG
44
Cromer •______ - black prenatal patient • The ab reacted to all other RBCs except hers and 2 siblings
Mrs. Cromer
45
Cromer •________ - complement regulatory protein (CD55 gene) • involved in the regulation of complement activation by accelerating the decay of C3 and C5 convertase • integral intrinsic membrane glycoprotein that is anchored by GPI
DAF (Decay Accelerating Factor)
46
Cromer • CHROMOSOME ____ •____ gene
1 CD55
47
Cromer • ANTIGENS •____ antigens • 15 (HF) - ***Tca and Dra;*** • 3 (LF) - ***Tcb and Tcc*** • Carried in____ • Expressed in_____ tissues
19 DAF placental
48
• Carried in DAF • Expressed in placental tissues
Cromer
49
Antigens • found in ***membranes of RBCS, plts, granulocytes, lymphocytes, placenta,*** and ***lower soluble quantities in plasma and urine*** • Expressed in ***cord cells*** • ***Negative in PNH cells***
Cromer
50
Cromer • Resistant to treatment with (3) • Sensitive to_____ • Weakened, not destroyed by (2)
ficin and papain, glycine-acid EDTA chymotrypsin AET and DTT
51
Cromer •NULL/WEAK PHENOTYPES •______ - Cromer null • ______phenotype - Weak Cromer expression
Inab Dr (a-)
52
Cromer ANTIBODIES • (2) • Implicated in HTRs but does not cause HDFN • (1)
Anti-Cra and Anti-Tca (IgG) Anti-IFC
53
Cromer Antibody •______ - has been associated with mild transfusion reactions but there are cases documented of Cra- transfused with Cra+ cells but no reaction
Anti-Cra

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