Uncommon Blood Group Prt. 2

Question 1

Knops

• (2) - low frequency Ags
• Other Ags - Present in 90% of populations

Answer 1

Knb and McCb

Question 2

• Antigens - poorly expressed on in cord cells and in pts with autoimmune disease and pts with Lu(a-b-) phenotype due to the influence of the In(Lu) gene.

Abs - does not cause HTR and HDFN

Answer 2

Knops

Question 3

Knops

•CHROMOSOME___
•____ gene

Answer 3

1

CR1

Question 4

Knops

• ANTIBODIES
•Clinically significant/ insignificant???
•____
•Detected with____

Answer 4

insignificant

IgG

AHG

Question 5

Knops

ANTIGENS
•____ antigens
•Weak expression on cord RBCs and weakens upon storage

• Weakened by (2)
• Destroyed by____;
• resistant to____

•_______PHENOTYPE

Answer 5

9

ficin and papain

DTT

glycine-acid EDTA

HELGESON

Question 6

Indian

______- high freq
- depressed in______ individuals

• InLu- depressed/ reduced_____

Answer 6

Inb

In(Lu)

CD44

Question 7

Indian

(ADHESION MOLECULE)
- found in only one individual presented with congenital dyserythropoietic anemia

Answer 7

In(a-b-)

Question 8

Indian

•CHROMOSOME____
•____ gene

Answer 8

11

CD44

Question 9

Indian

• ANTIGENS
• (2)
• Carried by____
• Weakly expressed on cord RBCS

Answer 9

Ina, Inb

CD44

Question 10

Indian

• Sensitive to (3)
• Resistant to (1)

Answer 10

ficin, papain, and DTT

acid-glycine EDTA

Question 11

Indian

NULL/WEAK PHENOTYPES
•_____
• Depressed on In (Lu) RBCs

Answer 11

In(a-b-)

Question 12

Indian

• ANTIBODIES
• (2)
•Enhanced by AHG
•Causes ____ but no ____

Answer 12

Anti-Ina and Anti-Inb (IgG)

HTR but no HDN

Question 13

OK

CHROMOSOME____
•____ gene

Answer 13

19

BSG

Question 14

OK

• ANTIBODIES
•______ is rare

• IgG
• Reactive on AHG test
• Reduced survival of red cells

Answer 14

Anti-Oka

Question 15

OK

ANTIGENS
•____ antigen
• Carried by____
• Well developed in newborns

• Resistant to treatment of (4)

Answer 15

Oka

CD147

ficin, papain, DTT, and glycine-acid EDTA

Question 16

OK

Oka - HF

(2)- additional antigens
- not reported to cause HDFN

Answer 16

OKGV, OKVM

Question 17

RAPH - the first patient to make the____

Answer 17

alloanti-MER2

Question 18

Raph

•CHROMOSOME___
•_____ gene

Answer 18

11

CD151

Question 19

Raph

• ANTIBODIES
•______
• May cause HTR, not HDN

•____ - monoclonal Ag,
Eleanor Roosevelt - the lab where the ab is produced

Answer 19

Anti-MER2 (IgG)

MER2

Question 20

Raph

ANTIGENS (found in CD151, tetraspanin)
•______
abundant in platelets and erythroid
precursors

• Resistant to (2)
• Sensitive to (5)

Answer 20

MER2 antigen

ficin and papain

trypsin, alpha-chymotrypsin,
pronase, and AET

Question 21

JMH

CHROMOSOME____
•_____ gene

Answer 21

15

SEMA7A

Question 22

JMH

• ANTIBODIES
•____
• Do not cause HTR or HDN

Answer 22

Anti-JMH (IgG)

Question 23

JHM

ANTIGEN
•________ (high prevalence)
• Found on RBCs, placenta, thymus, testes

• Weak on cord RBCs
• Sensitive to ficin, papain, and
• Resistant to glycine-acid
•_____\ - antigens recently added

Answer 23

JMH1 antigen

JMH2-6

Question 24

Gill

• CHROMOSOME____
• (MAJOR INTRINSIC PROTEIN WATER CHANNELS)

Answer 24

9

AQP3 gene - AQP3

Question 25

Gill ANTIGENS •_____ (lone antigen) • Carried by____ • Resistant to (2) • Enhanced by (2)

Answer 25

GIL AQP3 glycine-acid EDTA and DTT ficin and papain

Question 26

Gill • ANTIBODIES •____ • 37 degree Celsius • Enhanced by____ • Cause HTR but not HDFN

Answer 26

IgG AHG

Question 27

Rh-associated glycoprotein • CHROMOSOME____ - •_____ gene

Answer 27

6 RHAG

Question 28

Rh-associated glycoprotein • ANTIGENS (4)

Answer 28

• Duclos • Ol^a • DSLK • RHAG 4

Question 29

Rh-associated glycoprotein ANTIBODIES (4)

Answer 29

• Anti-Duclos • Anti-Ol^a • Anti-DSLK • Anti-RHAG 4

Question 30

FORS CHROMOSOME___ •_____ gene

Answer 30

9 GBGT1

Question 31

FORS • ANTIBODIES •______ • 4 degree Celsius • Unknown clinical significance

Answer 31

Anti-FORS1 (IgM)

Question 32

FORS ANTIGENS •______ • Addition of GalNac to P antigen • Enhanced with ficin and papain • Resistant to DTT and glycine-acid EDTA

Answer 32

FORS1

Question 33

• Receptor for E. coli

Answer 33

FORS1

Question 34

JR • CHROMOSOME___ •_____ gene

Answer 34

4 ABCG2

Question 35

JR • ANTIBODIES •______ • Causes HDFN and HTR

Answer 35

Anti-Jra (IgG)

Question 36

JR ANTIGENS •_____ • Fully-developed at birth • Resistant to (4)

Answer 36

Jra ficin, papain, DTT, glycine-acid EDTA

Question 37

LAN • CHROMOSOME___ •____ gene • Functions in heme synthesis

Answer 37

2 ABCB6

Question 38

LAN • ANTIBODIES •______\ • Causes HTR and mild HDFN

Answer 38

Anti-Lan (IgG)

Question 39

LAN ANTIGEN •_____ (99%) • Resistant to (4)

Answer 39

Lan ficin, papain, DTT and glycine-acid ED TA

Question 40

Vel • CHROMOSOME___ •_____ gene

Answer 40

1 SMIM1

Question 41

Vel • ANTIBODIES • ______ • Causes HTR and severe HDFN

Answer 41

Anti-Vel (IgG and IgM)

Question 42

Vel ANTIGEN •____ • Enhanced with to (2) • Resistant to (2)

Answer 42

Vel ficin and papain DTT and glycine-acid EDTA

Question 43

CD59 • CHROMOSOME___ •_____ gene • Membrane inhibitor of lysis

Answer 43

11 CD59

Question 44

CD59 • ANTIBODIES •_____

Answer 44

Anti-CD59.1 (IgG)

Question 45

CD59 ANTIGEN • • Enhanced by enzymes • Sensitive to DTT • Associated with PNH

Answer 45

CD59.1

Question 46

Augustine CHROMOSOME____ •_____ gene • equilibrative nucleoside transporter 2 (ENT2)

Answer 46

6 SLC29A1

Question 47

Augustine • ANTIBODIES •_______ • Causes severe HTR and mild HDFN •______ • Causes severe HDFN

Answer 47

Anti- Ata (IgG) Anti-AUG3