lincosamide Flashcards
1
Q
what is the agent
A
clindamycin
2
Q
mechanism of action
A
binds to 50s subunit preventing protein synthesis.
3
Q
mechanism of resistance
A
alterations to the 23s ribosomal subunit alterations to the 50s proteins of the receptor site, enzymatic inactivation,
4
Q
spectrum
A
gram (+): strep (20% resistance), S. aureus (30% resis). anaerobes: b fraglis (30-60% resis), clostridium, pepto, prevotella, fusobacter.
also treats toxoplasmosis and falciparum.
5
Q
does clindamycin treat gram (-)
A
no.
6
Q
clinical uses
A
alternative to beta-lactam for surgical prophy, alternative for skin/soft tissue caused by staph, alternative for toxo, combination with penicillin for toxic shock, combination with quinine for falciparum.
7
Q
adverse affects
A
diarrhea, pseudomembranous colitis.
