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Hematology Lecture > Lineage Specific Hematopoesis > Flashcards

Lineage Specific Hematopoesis Flashcards

(76 cards)

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1
Q

During the maturation of a normal red blood cell, there will be normal changes that will happen or occur in terms of the:

A

Size
Nucleus
Cytoplasm
Chromatin
Granules

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2
Q

Fill in the blanks:

The cytoplasm of an immature cell is usually _____ or _____ due to RNA content.

A

Blue
Basophilic

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3
Q

True or False

The more mature the cell, the more basophilic because of the less RNA.

A

False

The more mature the cell, the less basophilic because of the less RNA.

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4
Q

Fill in the blank:

In _____, the cytoplasm contains granules.

A

Myeloid

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5
Q

The _____ is also known as acidophilic or eosinophilic granules.

A

Red (Acidic) Dye

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6
Q

The _____ is also known as the basophilic granules.

A

Blue (Basic) Dye

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7
Q

Combined basic and acidic dye.

A

Neutrophilic Granules

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8
Q

Special feature of the maturation of erythrocytes cells.

A

Elaboration of Hemoglobin

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9
Q

There are how many Series of Maturation?

A

6 Series of Maturation

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10
Q

Fill in the blanks:

At the mature stage of the hemoglobin, the nucleus is apparently no longer necessary and eliminated by _____ or _____.

A

Nucleolysis
Extursion

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11
Q

Fill in the blank:

A good example of nucleolysis is _____.

A

Erythrocytes

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12
Q

Fill in the blank:

In the nuclear changes, the immature nucleus is round or oval and the nuclear chromatin is very delicate, fine, and linear and is called _____.

A

Euchromatin

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13
Q

Give the characteristics of Euchromatin:

A

Very delicate
Fine
Linear
Pale Blue
Uncondensed

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14
Q

Fill in the blank:

As the cells matures, chromatin stands increasingly coarse and clumped _____.

A

Heterochromatin

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15
Q

RBC Inclusion Bodies:

A

Pappenheimer
Howell Jolly Bodies
Heinz Bodies

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16
Q

WBC Inclusion Bodies:

A

Alder-Reilly

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17
Q

If the nucleus is hyposegmented, what condition is associated?

A

Pelger Huet Anomaly (Lack of Lamin B)

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18
Q

In the erythrocyte series, what is larger in terms of size?

A

Megaloblasts are larger than normal mature erythrocytes

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19
Q

3 Stem Cells:

A

Totipotent Stem Cells
Pluripotent Stem Cells
Multipotent Stem Cells

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20
Q

First recognizable cell in the series of granular poesis is the _____.

A

Myeloblasts

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21
Q

2 progenitors in the Human Hematopoesis:

A

Common Myeloid Progenitors
Common Lymphoid Progenitors

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22
Q

First recognizable erythroid precursor.

A

Pronormoblast (Rubriblast)

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23
Q

Basophilic Normoblast (Prorubricyte) is mistaken as Pronormoblast (Rubriblast). To differentiate, what are the criteria in distinguishing which of which?

A
  1. Prorubricyte has coarse chromatins
  2. Absence of nucleoli
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24
Q

First stage of Hemoglobin synthesis in Erythropoiesis.

A

Basophilic Normoblast (Prorubricyte)

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25
Polychromatic (Polychromatophilic) Normoblast (Rubricyte) can be mistaken as Lymphocytes. To differentiate, what are the criteria?
1. Lymphocytes have crushed velvet nucleus and cytoplasm is sky blue 2. In Rubricyte, nucleus is checker board and cytoplasm is muddy or gray
26
It is the last stage in the Erythropoiesis where the mitosis stops.
Polychromatic (Polychromatophilic) Normoblast (Rubricyte)
27
Orthochromic Normoblast (Metarubricyte) is also known as _____
Late Normoblast
28
Last stage to synthesize Hemoglobin in Erythropoiesis.
Reticulocyte
29
Last stage in bone marrow before release to the blood in Erythropoiesis.
Reticulocyte
30
Best indicators of bone marrow functions.
Reticulocyte Count
31
This stain is used to visualize Reticulocytes.
Supravital Stain
32
Reference Range of Reticulocyte in Adults.
0.5% to 1.5%
33
Reference Range of Reticulocyte in Newborn.
2% to 6%
34
Last stage in the Erythropoiesis.
Erythrocyte
35
If an Erythrocyte has no central pallor, it indicates what issue?
Spherocytes
36
Enumerate the Normoblastic Nomenclature for Erythroid Precursors:
Pronormoblast Basophilic Normoblast Polychromatic Normoblast Orthochromatic Normoblast Reticulocyte Erythrocyte
37
Enumerate the Rubriblastic Nomenclature for Erythroid Precursors:
Rubriblast Prorubricyte Rubricyte Metarubricyte Reticulocyte Erythrocyte
38
Enumerate the Erythroblastic Nomenclature for Erythroid Precursors:
Proerythroblast Basophilic Erythroblast Polychromic Erythroblast Orthochromic Erythroblast Reticulocyte Erythrocyte
39
Identify: Pronormoblast Size
12-20 um
40
Identify: Pronormoblast Nucleus to Cytoplasm Ratio
8:1
41
Identify: Pronormoblast Nucleoli
1-2
42
Identify: Pronormoblast Percentage in Bone Marrow
1%
43
Identify: Pronormoblast Transit Time in Bone Marrow
24
44
Identify: Pronormoblast Division
Mitosis (2)
45
Identify: Basophilic Normoblast Size
10-15um
46
Identify: Basophilic Normoblast Nucleus to Cytoplasm Ratio
6:1
47
Identify: Basophilic Normoblast Nucleoli
0-1
48
Identify: Basophilic Normoblast Percentage in Bone Marrow
1-4%
49
Identify: Basophilic Normoblast Transit Time in Bone Marrow
24
50
Identify: Basophilic Normoblast Division
Mitosis (4)
51
Identify: Polychromic Normoblast Size
10-12 um
52
Identify: Polychromic Normoblast Nucleus to Cytoplasm Ratio
4:1
53
Identify: Polychromic Normoblast Nucleoli
0
54
Identify: Polychromic Normoblast Percentage in Bone Marrow
10-20%
55
Identify: Polychromic Normoblast Transit Time in Bone Marrow
24
56
Identify: Polychromic Normoblast Division
Mitosis (16)
57
Identify: Orthochromic Normoblast Size
8-10 um
58
Identify: Orthochromic Normoblast Nucleus to Cytoplasm Ratio
1:2
59
Identify: Orthochromic Normoblast Nucleoli
0
60
Identify: Orthochromic Normoblast Percentage in Bone Marrow
5-10%
61
Identify: Orthochromic Normoblast Transit Time in Bone Marrow
48
62
Identify: Orthochromic Normoblast Division
Not applicable
63
Identify: Reticulocyte Size
8-10 um
64
Identify: Reticulocyte Nucleus to Cytoplasm Ratio
Not applicable
65
Identify: Reticulocyte Nucleoli
0
66
Identify: Reticulocyte Percentage in Bone Marrow
1%
67
Identify: Reticulocyte Transit Time in Bone Marrow and in Peripheral Blood
Bone Marrow = 1-2 days Peripheral Blood = 1 day
68
Identify: Red Blood Cell Size
Diameter = 6-8 um Thickness = 1.5-2.5 um
69
Identify: Red Blood Cell Nucleus to Cytoplasm Ratio
Not applicable
70
Identify: Red Blood Cell Nucleoli
0
71
Identify: Red Blood Cell Percentage in Bone Marrow
0
72
Identify: Red Blood Cell Transit Time in Bone Marrow and in Peripheral Blood
Bone Marrow = 0 Peripheral Blood = 120 days
73
Identify: Red Blood Cell Division
Not applicable
74
Enumerate the Granulopoiesis in chronological order:
Myeloblast Promyelocyte Myelocyte Metamyelocyte Non-segmented Granulocyte Segmented Granulocyte
75
The first or earliest recognizable granulocyte precursor
Myeloblasts
76
3 Types of Myeloblasts:
Type I - Nucleus is open Type II - Presence of primary granules Type III - Darker in color

Hematology Lecture (6 decks)

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