Lippincott - Nucleotide Metabolism Flashcards Preview

[OS 201] 3rd Exam > Lippincott - Nucleotide Metabolism > Flashcards

Flashcards in Lippincott - Nucleotide Metabolism Deck (42)
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1

composition of nucleoside

pentose sugar + base

2

composition of nucleotide

nucleoside + 1 or more phosphate groups

3

deoxyribose sugars are formed by removing the oxygen associated with which carbon of a ribose sugar?

2nd carbon

4

nitrogens of purine rings come from:

[1] glycine
[2] glutamine
[3] aspartate

5

carbons of purine rings come from:

[1] glycine
[2] carbon dioxide
[3] N-formyl-tetrahydrofolate

6

organ where purine rings are synthesized

liver

7

activated pentose that is a major part of purine and pyrimidine biosynthesis

PRPP

8

committed step in de novo synthesis of purines

synthesis of 5' phosphoribosylamine from PRPP and glutamine

9

parent purine nucleotide

inosine monophosphate

10

energy requirement for conversion of IMP to GMP

ATP

11

energy requirement for conversion of IMP to AMP

GTP

12

responsible for synthesis of nucleoside diphosphates

base specific nucleoside monophosphate kinase (adenylate kinase, guanylate kinase, etc)

13

responsible for synthesis of nucleoside triphosphates

nonspecific nucleoside diphosphate kinase

14

enzymes involved in salvage pathway for purines

[1] adenine phosphoribosyltransferase (APRT)
[2] hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

15

salvage pathway for purines - hypoxanthine is converted to:

IMP

16

salvage pathway for purines - guanine is converted to:

GMP

17

salvage pathway for purines - adenine is converted to

AMP

18

Lesch-Nyhan syndrome

x linked recessive disorder associated with complete deficiency of HGPRT --> inability to salvage hypoxanthine or guanine --> high uric acid due to excessive degradation

19

responsible for deoxyribonucleotide synthesis from ribonucleotides

ribonucleotide reductase

20

inhibitor of ribonucleotide reductase

dATP binding to allosteric sites

21

organ of degradation of purine nucleotides

liver

22

end product of purine degradation

uric acid

23

hydrolyze dietary DNA

deoxyribonucleases

24

hydrolyze dietary RNA

ribonucleases

25

product of DNA/RNA hydrolysis

oligonucleotides

26

hydrolyze oligonucleotides

pancreatic phosphodiesterases

27

responsible for removing phosphate groups from nucleotides

nucleotidases

28

carbons of pyrimidine come from;

[1] aspartic acid
[2] carbon dioxide

29

nitrogens of pyrimidine come from:

[1] R group of glutamine
[2] aspartic acid

30

regulated step in de novo pyrimidine synthesis

synthesis of carbamoyl phosphate from glutamine and carbon dioxide