LMP301 Lecture 16: Viral Hepatitis Flashcards Preview

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Flashcards in LMP301 Lecture 16: Viral Hepatitis Deck (111)
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1

Causes of hepatitis

1. drugs
2. toxins
3. bacteria
4. viruses
5. parasites

2

define: hepatitis

inflammation of the liver

3

drugs that may cause hepatitis

- anticonvulsants
- corticosteroids
- alcohol
- tylenol/asprin overdose

4

toxins that may cause hepatitis

- DDT
- mushrooms

5

bacteria that may cause hepatitis

- thyphoid fever

6

viruses that may cause hepatitis

- hepatitis A, B, C, D, E, G
- CMV
- EBV

7

parasites that may cause hepatitis

tapeworm

8

clinical symptoms of viral hepatitis

- enlarged liver
- elevated liver enzymes
- change colour of urine/feces
- accumulation of biliburin (jaundice)

9

on a virus particle, what can be used to identify the strain?

- ssDNA or RNA
- surface proteins (HBsAg)

10

define: antigen (Ag)

a substance (protein) that prompts the generation of antibodies -> immune response

11

define: antibody (Ab/IgG/IgM)

proteins produced by B-cells which play an immunological role; identify & neutralizes foreign particles through antigens

12

Which antibody is first released when there is an immune response? Which is released after?

IgM, then IgG

13

IgM indicates...

primary immune response

14

__ are produced during the primary immune response

memory lymphocytes

15

The virus particle is surrounded by...

capsule coat

16

The genetic material of virus is in the form of...

DNA or RNA (single or double stranded)

17

what is directly inside the capsule coat?

Viral nucleocapsid (HBcAg)

18

HBcAg

Viral nucleocapsid

19

HBeAg

particles associated with nucleocapsid

20

Where are HBeAg found?

inside the viral capsid (HBcAg)

21

When does the production change from IgM to IgG?

after mature B cells are formed

22

What is it called when IgG production begins and IgM production stops?

class-switching

23

class-switching is....

a stable change in the B-cell's genome, and is transmitted to all progeny cells

24

Lifecycle of a virus

1. enters hepatocyte (capsule coat removed), viral DNA moves to nucleus of host
2. viral dsDNA -> cccDNA -> template for viral mRNA
3. viral mRNA transcription & assembly of new viral particles
4. viral proteins assemble around DNA core
5. new viral particles released from outer membrane of the host

25

dsDNA -[?]-> cccDNA

cellular enzymes

26

___ can persist in the hepatocyte during chronic infection

cccDNA

27

cccDNA is genetic material of...

virus

28

Steps of viral reproduction

1. Uncoating
2. Repair (formation of cccDNA)
3. Transcription
4. Translation

29

How does release of viral particles determine host cell health?

If a little bit of the particle is released at a time, host lives
if all released, host dies

30

If the host cell dies, what happens to the viral production cycle?

it halts