Flashcards in LMP301 Lecture 16: Viral Hepatitis Deck (111)
Causes of hepatitis
inflammation of the liver
drugs that may cause hepatitis
- tylenol/asprin overdose
toxins that may cause hepatitis
bacteria that may cause hepatitis
- thyphoid fever
viruses that may cause hepatitis
- hepatitis A, B, C, D, E, G
parasites that may cause hepatitis
clinical symptoms of viral hepatitis
- enlarged liver
- elevated liver enzymes
- change colour of urine/feces
- accumulation of biliburin (jaundice)
on a virus particle, what can be used to identify the strain?
- ssDNA or RNA
- surface proteins (HBsAg)
define: antigen (Ag)
a substance (protein) that prompts the generation of antibodies -> immune response
define: antibody (Ab/IgG/IgM)
proteins produced by B-cells which play an immunological role; identify & neutralizes foreign particles through antigens
Which antibody is first released when there is an immune response? Which is released after?
IgM, then IgG
primary immune response
__ are produced during the primary immune response
The virus particle is surrounded by...
The genetic material of virus is in the form of...
DNA or RNA (single or double stranded)
what is directly inside the capsule coat?
Viral nucleocapsid (HBcAg)
particles associated with nucleocapsid
Where are HBeAg found?
inside the viral capsid (HBcAg)
When does the production change from IgM to IgG?
after mature B cells are formed
What is it called when IgG production begins and IgM production stops?
a stable change in the B-cell's genome, and is transmitted to all progeny cells
Lifecycle of a virus
1. enters hepatocyte (capsule coat removed), viral DNA moves to nucleus of host
2. viral dsDNA -> cccDNA -> template for viral mRNA
3. viral mRNA transcription & assembly of new viral particles
4. viral proteins assemble around DNA core
5. new viral particles released from outer membrane of the host
dsDNA -[?]-> cccDNA
___ can persist in the hepatocyte during chronic infection
cccDNA is genetic material of...
Steps of viral reproduction
2. Repair (formation of cccDNA)
How does release of viral particles determine host cell health?
If a little bit of the particle is released at a time, host lives
if all released, host dies