Local anesthetics

Question 1

local anesthetics MOA

Answer 1

reduce the influx of sodium ions, prevent depolarization of the membrane and blcoking conduction of action potential

Question 2

amides example and where is it metabolised

Answer 2

metabolized in the liver
ex: lidocaine

Question 3

esters example and where is it metabolised

Answer 3

metabolised in plasma
more toxic and more allergic than amides
cocaine is an example

Question 4

lidocaine uses

Answer 4

AV nodal arrythmias , especially prohylaxis

Question 5

which amide is faster and longer acting as well as safest in children

Answer 5

lidocaine

Question 6

lidocaine AE

Answer 6

CNS excitation
seizures
vasodilation
hypotension
arrythmias