Examples
Furosemide
Bumetanide
MoA
NA+/K+/2Cl- co-transporter in LoH
Inhibitor
Reduces Na+, K+, Cl- reabsorption
Most powerful diuretic = Excretion of 15-25% filtered Na+
Indications
Oedema
Congestive Heart Failure
ADR
Oto + Nephrotoxicity Hypotension Hyponatraemia/kalaemia Hypercalcaemia Increase pH and Urea
PRESCRIBING ADVICE
X w/ Aminoglycosides or NSAIDs