Lymphoid Tissue (Exam II) Flashcards

1
Q

Lymphoid tissue organized into discrete structures or organs

A

Dense lymphoid tissue

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2
Q

Lymph nodes, spleen, thymus, & tonsils are all examples of:

A

Dense lymphoid tissue

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3
Q

Lymphoid tissue located throughout the body, associated with mucus membranes

A

Diffuse lymphoid tissue

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4
Q

Dense and diffuse tissue both contain a large number of ______ cells

A

Lymphocytes

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5
Q

Diffuse tissue is commonly seen in respiratory and digestive tracts as:

A

MALT

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6
Q

Lymphoid tissue where B and T cells acquire surface receptors

A

Primary lymphoid tissue

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7
Q

In primary lymphoid tissue, the B cells are located in the _____ while the T-cells are located in the _____

A

B cells—-> bone marrow

T cells ——> thymus

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8
Q

Mature B and T cells that secondarily migraine to all other lymphoid tissue are refferred to as:

A

Secondary lymphoid tissue

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9
Q

Malignant tumors of the immune system are refferred to as ____ when they involve solid organs and as _____ when they involve the blood

A

Lymphomas; leukemia

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10
Q

Circulating immune cells that are neoplastic

A

Leukemia

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11
Q

Network of blind ended vessels in connective tissue:

A

Lymphatic vessels

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12
Q

Lymphatic vessels provide a route which allows cells and large molecules in the ECS to:

A

Re-enter bloodstream

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13
Q

Lymphatic vessels assist circulation of _____, and concentrate _____ for elimination within lymph nodes

A

Lymphocytes; concentrate antigen

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14
Q

Encapsulated aggregates of lymphocytes & lymphoid tissue, distributed throughout the body

A

Lymph nodes

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15
Q

Lymph nodes are arranged in _____ or ____ along vessels of lymphatic origin

A

Chains or clusters

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16
Q

Areas where we find lymphnodes:

A

Submandibular, cervical , axillary, femoral, popliteal, and hilar

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17
Q

What are the 4 functions of lymph nodes:

A
  1. Non specific filtering of particulate matter and microorganisms form lymph
  2. Interaction of circulating lymphocytes with antigen in lymph
  3. Aggregation, activation, and proliferation of B cells with subsequent antibody production
  4. Aggregation & proliferation of T cells and induction of cytotoxic immunity
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18
Q

Due to the presence of macrophages, lymphnodes are:

A

Self-cleaning

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19
Q

Lymphocytes of all types, derived from the bone marrow:

A

Lymphoid cells

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20
Q

Lymphoid cells enter the lymph node via:

A

Bloodstream

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21
Q

Antigen presenting cell found within the lymph node:

A

Immune accessory cell

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22
Q

Immune accessory cells include:

A

Macrophages, B-cells, T-cells

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23
Q

Immune accessory cells (macrophages, B-cells, T-cells) originate in the:

A

Bone marrow

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24
Q

Immune accessory cell- macrophages at the periphery of germinal centers; antigen-presenting cells:

A

Follicular dendritic cells

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25
Q

Immune accessory cell- primarily found in germinal center that possess numerous phagocytic vesicles

A

Tingible body macrophage

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26
Q

Fibroblasts and reticular cells (fibroblasts like cells with phagocytic capability)

A

Stromal cells

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27
Q

What forms the connective tissue skeleton of lymph nodes?

A

Stromal cells and extracellular products

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28
Q

The lymph node contains an outer, fibrous _____ of dense irregular connective tissue

A

Capsule

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29
Q

Grossly, lymphnodes have dense, outer, cellular ______ and a less cellular inner _____

A

Cortex; medulla

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30
Q

What type of cells are found in the outer cellular cortex of lymph nodes?

A

B-cells, T-cells, & plasma cells

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31
Q

The medulla of lymph node is less cellular than the _____.

A

Cortex

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32
Q

Extensions of cortical tissue into the medulla of the lymph node

A

Medullary cords

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33
Q

The medullary cords of the lymph node are separated by broad lymphatic channels called:

A

Medullary sinuses

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34
Q

Interspersed throughout the cortex of the lymph node are very thin, collagenous:

A

Trabeculae

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35
Q

Blood vessels enter and leave the lymph node at the:

A

Hilus

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36
Q

Process of B- cells and T-cells leaving the blood stream and entering the lymph node

A

Diapedesis

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37
Q

Diapedesis is facilitated by complimentary:

A

Adhesion molecules

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38
Q

The complementary adhesion molecules that facilitate diapedesis of b and t-cells:

A

Addressins

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39
Q

Adressins are present on both:

A

Endothelial cells and lymphocytes

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40
Q

During diapedesis, the b and T cells migrates across the walls of specialized:

A

Post-capillary venules

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41
Q

Post capillary venules are considered:

A

High endothelial venules

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42
Q

Post capillary venules are lined by:

A

Cuboidal to columnar endothelium

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43
Q

Post capillary venules are located in the deep inner cortex of the lymph node at the ____ junction or _____ zone.

A

Corticomedullary junction or paracortical zone

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44
Q

Space beneath the capsule where numerous afferent lymph vessels drain into:

A

Cortisol/subcapsular sinus

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45
Q

The lymphatic vessels that drain into the cortical or subcapsular sinus are _____ lymph vessels

A

Afferent

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46
Q

In the lymph node: The endothelium of sinus on the side adjacent to the capsule is ______ to prevent leakage, but _____ on the side adjacent to the parenchyma.

A

Continuous; discontinuous

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47
Q

The lymphatic sinuses are not open spaces like blood sinuses, but rather are filled with:

A

Reticular fibers and macrophage processes

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48
Q

The sinuses of the lymph nodes that are located in the cortex:

A

Cortical sinuses, trabecular sinuses, peritrabecular sinuses

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49
Q

broad lymphatic channels in the inner, less cellular medulla:

A

Medullary sinuses

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50
Q

The medullary sinuses contain what type of cells?

A

Lymphocytes, plasma cells, monocytes

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51
Q

The medullary sinuses converge on the:

A

Hilus

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52
Q

Lymph drains from the hilus of the node via:

A

Single efferent lymph vessel

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53
Q

Eventually, lymph returns to the bloodstream via the:

A

Thoracic duct or right lymphatic ducts

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54
Q

Lymphatic drainage to regional lymph node is important in:

A

Metastasis of tumor cells

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55
Q

Within the cortex of the lymph node are densely packed, highly cellular:

A

Lymphoid follicles

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56
Q

Lymphoid follicles can also be called:

A

Lymphatic nodules or primary follicles

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57
Q

Lymphoid follicles may contain a paler, less dense ______.

A

Germinal center

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58
Q

If a germinal center is present in a lymphoid follicle, the follicle is considered:

A

Secondary follicle

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59
Q

A secondary follicle (germinal center present) indicates the node is:

A

Responding to antigen

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60
Q

Lymphocytes respond to antigen by increasing antibody production via:

A

Clonal expansion

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61
Q

secondary follicles are sites of _____ .

A

B-cell proliferation

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62
Q

secondary follicles (sites of b-cell proliferation) can be referred to as:

A

Secondary hemopoiesis

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63
Q

What cells are present at sites of B-cell proliferation (secondary hemopoiesis): (4)

A

Lymphoblasts, macrophages, immature b & T cells

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64
Q

Proliferation of lymphocytes (within the lymph node) results in:

A

Englarment and swollen lymph node

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65
Q

The dark staining rim around the germinal center of the lymph node is called the:

A

Mantle zone

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66
Q

The mantle zone of the germinal center of the lymph node is the region of:

A

Antigen presentation

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67
Q

The organization of lymphocytes in the cortex of the lymphnode is NOT:

A

Uniform

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68
Q

The secondary follicle of lymph node is light staining due to:

A

Lots of cytoplasm

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69
Q

Lobular lymphatic organ located in the mediastinum:

A

Thymus

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70
Q

The thymus is embryologically derived from:

A

Epithelial outgrowth of 3rd pharyngeal pouch

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71
Q

Important hematopoietic organ during fetal development

A

Thymus

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72
Q

the thymus is similar in appearance to the lymph node but lacks ____ and the medulla lacks _____

A

Lymphoid follicles ; medullary cords and sinuses

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73
Q

The thymus has a ______ of dense, irregular connective tissue:

A

Thin capsule

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74
Q

The thymus contains slender _____ or _____ that divide the thymus into lobules

A

Interlobular septa or trabeculae

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75
Q

The thymus has a darker staining ____ and a paler _____.

A

Cortex ; medulla

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76
Q

The functions of the thymus: (4)

A
  1. Production of mature immunocompetent Th (helper T cell) and Tc cells (cytotoxic T cells)
  2. Clonal proliferation of cytotoxic T cells
  3. Clonal deletion of self antibodies
  4. Secretion of hormones regulating T cell development and maturation
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77
Q

The clonal deletion of self antibodies of the thymus aids in the development of:

A

Immunologic self tolerance

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78
Q

In the thymus, failure of clonal deletion of self antibodies may result in:

A

Autoimmune diseases

79
Q

As t- cells mature they express: (3)

A
  1. Antigen specific t-cell receptors
  2. CD surface markers (cluster of differentiation)
  3. Class 1 and 2 HLA (human leukocyte Ag) surface markers
80
Q

The thymus contains a highly cellular cortex packed with:

A

Lymphocytes, mostly t-cells and macrophages

81
Q

What is absent in the thymus?

A

Secondary follicles

82
Q

The lack of secondary follicles in the thymus causes limitations resulting in only:

A

Local expansion of T-cells

83
Q

Place where t-cells migrate to become immune competent:

A

The thymic cortex

84
Q

In the thymus, the less cellular control medulla contains mostly:

A

B-cells, plasma cells & macrophages

85
Q

Epithelial cells within the thymus that provide structural and physiological support:

A

Nurse cells

86
Q

_____ cells in the thymus secrete hormones that collectively regulate T cell proliferation & differentiation

A

Nurse cells

87
Q

What 3 hormones do nurse cells secrete?

A
  1. Thymotaxin
  2. Thymosin
  3. Thymopoeitin
88
Q

Attract, regulate & promote t-cell proliferation and differentiation into cytotoxic T cells, helper T cells & suppressor T cells

A

Thymotaxin, thymosin, thymopoeitin

89
Q

Eosinophilic lamellated structures within both the cortex and medullary of thymus that represent degenerate reticular and epithelial nurse cells

A

Hassal’s corpuscles

90
Q

What type of cells to hassal’s corpuscles represent?

A

Degenerate nurse cells

91
Q

What organ degenerates at puberty and is vestigial in adults?

A

Thymus

92
Q

The thymus undergoes: (in adults)

A

Fatty infiltration & lymphatic depletion

93
Q

The thymus undergoing fatty infiltration and lymphatic depletion is called:

A

Thymic inovlution

94
Q

The thymus contains contains an inner surface of capsule lined by ______ to isolate the thymus

A

Continuous epithelium

95
Q

because T-cells are not fully differentiated, there are no ______ lymph vessels to the thymus, only _____ vessels for lymph drainage.

A

Afferent; efferent

96
Q

Thymic blood vessels are also surrounded by a connective tissue sheath called:

A

Blood-thymus barrier

97
Q

The blood thymus barrier forms continuous:

A

Continuous antigenic barrier

98
Q

What isolates the thymus from immune cells:

A

Thymus barrier

99
Q

The connective tissue sheath ) the blood-thymus barrier) consists of a wide variety of cells & fibers including:

A

Epithelioreticular cells
Reticular fibers
fibroblasts
Macrophages
Plasma cells

100
Q

The blood thymus barrier surrounds the:

A

Endothelium and basement membrane of blood vessels

101
Q

What is important in maintaining the integrity of the thymus?

A

The blood-thymus barrier

102
Q

What is the largest lymphoid organ in the body?

A

Spleen

103
Q
  1. B & T cell replication, manufacture of antibody and antigen removal
  2. Removal of particulate matter, aged or defective RBCs from circulation via phagocytosis
  3. Recycling of Fe from Hb
  4. Hemopoiesis in the fetus
A

Spleen function

104
Q
  1. Non-specific filtering of particulate matter & microorganisms from lymph
  2. Interaction with circulating lymphocytes with antigen in lymph
  3. Aggregation , activation, and proliferation of B cells with subsequent antibody production
  4. Aggregation and proliferation of T cells & induction of cytotoxic immunity
A

Lymph node function

105
Q
  1. Production of mature immunocompetent helper, and cytotoxic T cells
  2. Clonal proliferation of cytotoxic T cells
  3. Clonal deletion of self antibodies
  4. Secretion of hormones regulating T cell development and maturation
A

Thymus functions

106
Q

If the spleen is removed, function is taken over by the:

A

Liver and bone marrow

107
Q

Describe the capsule of the spleen:

A

Dense- fibro-elastic outer capsule

108
Q

The dense fibro-elastic outer capsule of the spleen contains _____ cells important in ______.

A

Smooth muscle cells ; splenic contraction

109
Q

In some species, the spleen acts as a:

A

Reservoir for red blood cells

110
Q

Characteristic large thick bands of dense connective tissue that extend into the body of the spleen:

A

Trabeculae

111
Q

The trabeculae of the spleen contain:

A

Trabecular arteries and veins

112
Q

Unlike lymphnodes & thymus, the spleen lacks:

A

Cortex & medulla

113
Q

The bulk of the spleen is composed of spongy matrix of:

A

Red pulp

114
Q

Within the red pulp of the spleen are: (2)

A

Pulp cords and sinusoids

115
Q

The sinusoids within the red pulp of the spleen contain:

A

Mostly blood

116
Q

The pulp cords (cords of Bilroth) within the red pulp of the spleen are more cellular and contain:

A

Large #’s of macrophages & lymphocytes

117
Q

The pulp cords within the red pulp of the spleen are supported by connective tissue skeleton of:

A

Reticular cells & reticular fibers

118
Q

Scattered throughout the red pulp are discreet nodules of ______ which contain large #’s of _______.

A

White pulp; WBCs

119
Q

Areas of white pulp are considered ______ areas that may or may not have ______.

A

Follicular areas that may or may not have germinal centers

120
Q

The germinal centers of the follicular areas of white pulp contain primarily:

A

B-cells

121
Q

Located within the white pulp of the spleen is a:

A

Central artery

122
Q

The areas of white pulp are surrounded by a thin basophilic ____ which is further surrounded by a paler ____.

A

Mantle zone; marginal zone

123
Q

The white pulp functions as a site of:

A

Antigen presentation & phagocytosis

124
Q

The white pulp of the spleen contains large numbers of:

A

Macrophages, plasma cells & helper T cells

125
Q

Enlarged germinal centers of the spleen visible to the naked eye

A

Splenic nodules

126
Q

Central arteries of the spleen are surrounded by _____ and form ______.

A

T-cells; PALS

127
Q

PALS:

A

Periarteriolar lymphatic sheaths

128
Q

PALS lack _____ because they have minimal ____.

A

Germinal centers; T-cell proliferation

129
Q

PALS are less well-developed in:

A

Humans

130
Q

What term is used interchangeable with primary follicles in white pulp?

A

PALS

131
Q

PALS should always be referring to ______ foci

A

T-cell

132
Q

Branches of splenic arteries enter the spleen within trabeculae via the _______, and branch and form _____ to white pulp.

A

Trabecular arteries; central arteries

133
Q

The central arteries of the spleen continue into the red pulp, where they branch into perpendicular:

A

Penicillar arteries

134
Q

The penicillar arteries of the red pulp branch into _____ and then terminate into 2-3 ______.

A

Arterioles ; sheathed capillaries

135
Q

Blind end capillaries that lack endothelial lining and are surrounded by macrophages.

A

Sheathed capillaries

136
Q

The sheathed capillaries form a non-continuous:

A

Perivascular sheath or cuff

137
Q

The perivascular sheath act as part of the _____, active in phagocytosis

A

Filtering mechanism

138
Q

Blood cells leave the sheathed capillaries via _____.

A

Diapedesis

139
Q

Blood cells leave the sheathed capillaries via diapedesis and enter the ______ of ______.

A

Sinuses of red red pulp

140
Q

The sinusoids of the spleen are lined by endothelial cells called:

A

Stave cells

141
Q

_____ between stave cells allow for free passage of blood cells

A

Endothelial slits

142
Q

Blood drains out of the spleen via:

A

Trabecular venules

143
Q

After the blood drains out of the spleen through trabecular venules, it empties into:

A

Splenic vein

144
Q

What type of circulation is found within the spleen?

A

Open circulation

145
Q

Paired structures located at the junction of oral and pharyngeal cavities:

A

Palatine tonsil

146
Q

The palatine tonsil is located within:

A

Tonsillar crypts

147
Q

The tonsillar crypts that house the palatine tonsil are located between anterior and posterior _____.

A

Tonsillar pillars

148
Q

Anterior tonsillar pillar:

A

Palatoglossal arch

149
Q

Posterior tonsillar pillar:

A

Palatopharyngeal arch

150
Q

Tonsils located at the base of tongue:

A

Lingual tonsils

151
Q

Pharyngeal tonsils are also called:

A

Adenoids

152
Q

Location of the pharyngeal tonsils/adenoids? What are they associated with?

A

Nasopharynx ; eustachian tubves

153
Q

Palatal, lingual, and pharyngeal tonsils are collectively referred to as:

A

Waldeyer’s ring

154
Q

The ring of immunological protection around the GI and respiratory tracts:

A

Waldeyer’s ring

155
Q

Palatal and pharyngeal tonsils are collectively referred to as:

A

NALT

156
Q

NALT

A

Nasal associated lymphoid tissue

157
Q

The palatine tonsil is similar to lymph nodes but it is:

A

Unencapsulated

158
Q

The base of the palatine tonsil is supported by:

A

Collagenous hemicapsule

159
Q

The palatine tonsil contains no distinct:

A

Cortex or medulla

160
Q

In the palatine tonsil, lymphoid follicles are scattered through the _______, and may include ______.

A

Parenchyma; germinal centers

161
Q

Luminal surface of palatine and lingual tonsils is covered by:

A

Stratified squamous non-keratinized epithelium (SSNKE)

162
Q

The stratified squamous non-keratinized epithelium invades the tonsils forming blind-ended:

A

Tonsilar crypts

163
Q

Organ containing cortex with primary and secondary follicles & medulla with medullary cords and sinusoids

A

Lymph node

164
Q

Organ containing mostly T-cells, not b-cells; hassal’s corpuscles; cortex and medullar present

A

Thymus

165
Q

Organ containing robust capsule and trabeculae; no cortex & medulla, red and white pulp instead:

A

Spleen

166
Q

Organ containing hemicapsule and skin-like epithelium with crypts, not cortex & medulla

A

Palatine tonsile

167
Q

Blind ended sack, vestigial cecum

A

Appendix

168
Q

The appendix ____ in adults

A

Atrophies

169
Q

The appendix contains mostly _____ cells.

A

B-cells

170
Q

_____ is an important digestive organ in herbivores & used for bacterial fermentation

A

Appendix

171
Q

Most organized structure of diffuse lymphoid tissue:

A

Appendix

172
Q

MALT in the gut:

A

GALT

173
Q

MALT in respiratory tract:

A

BALT

174
Q

MALT in pharynx:

A

NALT

175
Q

Diffuse unencapsulated lymphoid aggregates associated with mucosal surfaces:

A

MALT

176
Q

MALT is located in the ______ tissue of the _____.

A

Subepithelial connective tissue ; lamina propria

177
Q

What type of cells are primarily present in MALT?

A

B-cells

178
Q

MALT primarily produces:

A

IgA (secretory IgA)

179
Q

Similar to lymph nodes, MALT may contain

A

Germinal centers

180
Q

Samples antigenic material, produces lymphoblasts, and secretes antibody:

A

MALT

181
Q

Malt in the gut contains specialized:

A

M-cells

182
Q

M-cells of MALT in the gut are:

A

Squamoid enterocytes

183
Q

M-cells (squamoid enterocytes) are located in surface epithelium with _____ on surface

A

Micro folds (NOT MICROVILLI)

184
Q

MALT is responsible for antigen sampling and transfer from ______ into ______.

A

Gut lumen into lymphoid follicles

185
Q

MALT is formed during:

A

fetal development

186
Q

MALT distribution is maximum in _______ and progressively atrophies with ______.

A

Childhoood; age

187
Q

Special type of MALT scattered throughout the small intestine:

A

Peyer’s Patches

188
Q

Peyer’s Patches are most common in the ______ and least common in the _______.

A

Ileum ; duodenum

189
Q

Peyer’s Patches project into the lumen of gut in _______ with cuboidal mucosa

A

Dome areas

190
Q

Peyer’s patches also contain ______ cells.

A

M-cells

191
Q

Peyer’s patches are histologically similar to:

A

MALT

192
Q

Peyers’s patches are lymphoid aggregates that contain large numbers of:

A

B & T cells

193
Q

Peyer’s patches ____ produce appreciable quantities of IgA

A

DO NOT

194
Q

_____ are frequent in Peyer’s patches and are associated with foci of B-cells

A

Germinal centers