Macrocytic Anemia

Question 1

Megaloblastic anemia leads to?

Answer 1

hypersegmented neutrophils , glossitis.

Question 2

Folate vs B12 def?

Answer 2

Folate: Increased homocysteine, normal methylmalonic acid and No neurologic symptoms

B12=>Increased homocysteine, Increased methylmalonic acid and neurologic symptoms (Subacute degeneration)

Question 3

Subacute degeneration?

Answer 3

You lose DCML and Lateral Corticospinal Tract

Question 4

Folate is absorbed in the?

Answer 4

Jejunum

Question 5

Where is B12 absorbed?

Answer 5

Ileum

Question 6

B12 def takes?

Answer 6

Years to develop

Question 7

Orotic Aciduria vs Orthinine Trantranscarbamylase deficiency?

Answer 7

Orotic Aciduria=>No Hyperammonium

Orthinine Trantranscarbamylase deficiency=>urea cycle=> increased orotic acid+hyperammonia