Macrolides Flashcards Preview

Z A Pharm III > Macrolides > Flashcards

Flashcards in Macrolides Deck (13):
1

What is MOA for macrolides

inhibit RNA protein synthesis (50S)

2

What is bacterias MOR for macrolides

altered target
drug efflux

3

What are the types of macrolides

Erythromycin
Clarithromycin
Azithromycin
- 500 mg 1 day then 250 mg qd 4 days

4

What does erythromycin treat

Strep
Staph
G -
Clostridium
atypical pneum
bordetella pertussis
treponema pallidum
ricettsia

5

What does body do to erythromycin

25% bioavailable
No CNS or CSF
Excreted bile

6

What are common uses of erythromycin

DOC - bordetella pertussis

7

What are adverse effects of erythromycin

N/V/D
hearing loss
QT prolong
warfarin and other drugs

8

What does clarithromycin treat

same as erythromycin
M. A. C.
borrelia burgdorferi
babesia microti

9

What does body do to clarithromycin

50% bioavailable
alverolar macrophages
excrete urine

10

What are adverse effects of clarithromycin

warfarin and other drugs

11

What does azithromycin treat

same as erythromycin
atypicals
STI: chlamydia, ureaplasma, gonorrhea
treponema pallidum

12

What are common uses of azithromycin

STI
URI
CAP

13

What are adverse effects azithromycin

D/N/V