Major Histocompatibility Complex (MHC) BLOCK 6 Flashcards
(52 cards)
What kind of cells produce MHC?
All nucleated cells
Human leukocytes antigens
Mom will produce antibodies to father WBC.
HLA responsible for tissue transplant rejection
What is another name for HLA?
MHC. That’s what we use more
______ first identified as important in rejection of tissue transplant
MHC
What kind of cells produce MHC I
All nucleated cells
What kind of cells produce MHC II
B-cells and Antigen presenting cells.
CD-8 recognizes what kind of MCH
MHC I
What kind of MHC does CD4 recognize
MHC II
What kind of MHC do neutrophils produce
MHC I
Why does liver not have MHCI
Because it cleans things, sees a lit of foreign material
Does placenta have MHC?
No, because fetus is foreign and you don’t want to attack a fetus
What is a key player in the normal immune response
MHC
CD-8 recognizes
MHC class I
CH-4 recognizes
MHC class II
Where is MHC located?
On the short arm of chromosome 6
What ar the 3 major loci of MHC class I
A, B, C
Which MHC plays a bigger role in organ transplant
MHC I
What are the three major loci for MHC II
DP, DQ, DR
What is the one major loci for MHC I
B
What is the one major loci for MHC II
DR
What T cell plays a big role in tissue rejection
CD 4
Why is MHC class 1 omnipresent
Every cell become cancerous/infectious. Have to have way to clear cells that are not part of immune system
Endogenous antigens
From within the cell.
MHC I, CD-8
Not phagocytized
What kind of antigens for MHCI?CD8
Endogenous
