MDS PART 1 Flashcards
(37 cards)
Results from clonal abnormalities of hematopoietic pluripotential cells
MDS (Myelodysplastic Syndromes)
Group of acquired clonal hematologic disorders characterized by progressive CYTOPENIA defective erythroid, myeloid and
megakaryocytic maturation.
MDS (Myelodysplastic Syndromes)
- “Pre-Leukemias”
MDS (Myelodysplastic Syndromes)
A. Age:______
B. Peripheral blood:___________
C. Myeloid cell lines: __________
D. Clinical course: _______________
Morphologic Abnormalities leading to MDS
1) Dyserythropoiesis
2) Dysmyelopoiesis
3) Dysmegakaryopoiesis
-Evident when RBC precursors has abnormal nucleus, nuclear fragments, internuclear bridging and ring sideroblast.
1) Dyserythropoiesis
-persistence of basophilia in the cytoplasm of WBC
2) Dysmyelopoiesis
–changes include giant platelets and abnormal platelet granulation, either hypogranulation or agranulation.
3) Dysmegakaryopoiesis
Two types of MDS:
a) Primary MDS
b) Therapy Related MDS:
-Environmental exposure
a) Primary MDS
-Mutations caused by chemical, radiation, viral infection or smoking
a) Primary MDS
-Genetic inheritance of hematologic disorders.
a) Primary MDS
- Chemotherapy
b) Therapy Related MDS
- Radiotherapy
b) Therapy Related MDS
- Administration of Cytokines (G-CSF or GM-CSF)
b) Therapy Related MDS
Classification of MDS
FAB CLASSIFICATION
WHO CLASSIFICATION
Retains FAB features
WHO CLASSIFICATION
Recognizes molecular, cytogenetic, and immunologic characteristics
WHO CLASSIFICATION
Removed categories of CMML and RAEB-t and placed them in MDS/MPD and acute leukemia.
WHO CLASSIFICATION
Relies on morphology
FAB CLASSIFICATION
Does not address therapy-related or hereditary forms
FAB CLASSIFICATION
