Medical Onco, Hema And Coag

Question 1

To which platelet glycoprotein does Vol Willebrand factor bind to enhance platelet aggregation

Answer 1

Glycoprotein Ib

Question 2

Fibrinogen forms BRIDGES between activated platelets by binding to which platelet glycoprotein

Answer 2

Glycoprotein IIb/IIIa

Question 3

Chromosomal abnormality in Burkitt’s lymphoma

Answer 3

Chromosomal translocation (8:14)

Question 4

Neoplasm associated with Beta-napthylamine

Answer 4

Bladder cancer

Question 5

Activated factor X (Xa), in combination with which 2 cofactors, activates prothrombin on the surface of platelets

Answer 5

Ionized calcium
Factor Va

Question 6

Complex activates protein C on the surface of endothelial cells

Answer 6

Thrombin-thrombomodulin complex

Question 7

Most central natural anticoagulant protein

Answer 7

Antithrombin III

Question 8

Major endogenous activators of plasminogen

Answer 8

Tissue plasminogen activator (tPA) and
Urokinase

Question 9

Prevents the reduction of Vit K once it has functioned as a cofactor for carboxylation of factor II, VII, IX and X

Answer 9

Sodium warfarin (Coumadin) as an anticoagulant

Question 10

MC lab abnormality associated with antiphospholipid syndrome

Answer 10

Elevated aPTT not corrected by normal plasma

Question 11

Laboratory test of hemophilia A

Answer 11

Prolongation of aPTT

Question 12

Molecular abnormality in hemophilia B

Answer 12

X-linked recessive deficiency of factor IX (Christmas Factor)

Question 13

MOA of METHOTREXATE

Answer 13

Binds dihydrofolate reductase, preventing reduction of folate to tetrahydrofolate, which is necessary for production of thymidine purines

Question 14

Best tumor marker for choriocarcinoma

Answer 14

Beta-hCG

Question 15

MOA of PACLITAXEL

Answer 15

Enhancement of tubulin polymerization

Question 16

Drug usually associated with hemolytic uremic syndrome

Answer 16

Mitomycin C

Question 17

Factors shift the oxygen curve to the RIGHT

Answer 17

High CO2
Low pH (Acidosis)
High DPG
High Temp

Question 18

Only clotting factor NOT made in liver

Answer 18

Factor 8

Question 19

Clotting abnormalities in Von Willibbrand disease

Answer 19

Long PTT and long bleeding time or functional platelet assay

Question 20

Drug tx for Gestational trophoblastic neoplasm

Answer 20

Actinomycin D
MOA: blocks RNA synthesis by intercalating DNA nucleotide pairs

Question 21

Most significant side effect associated with BLEOMYCIN

Answer 21

Interstitial pneumonitis

Question 22

Most important factor in predicting efficacy of progestin therapy in endometrial cancer

Answer 22

Progesterone receptor status of tumor

Question 23

Finding in peripheral blood smear characteristic of surgical or functional splenectomy

Answer 23

Howell-jolly bodies

Question 24

Storage form of iron

Answer 24

Ferritin

Question 25

Hemolytic anemia associated with ulcerative colitis

Answer 25

Autoimmune hemolytic anemia

Question 26

A graft placed in the anatomic position normally occupied by such tissue

Answer 26

Orthotopic graft

Question 27

Chromosome contains the Major Histocompatibility Complex (MHC)

Answer 27

Chromosome 6

Question 28

MHC antigens bets trigger the proliferation of allogenic lymphocytes

Answer 28

HLA class II antigen (HLA-D, DR, DQ, and DW/DR)

Question 29

Cells that have HLA Class I molecules

Answer 29

All nucleated cells

Question 30

Cells that have HLA Class II molecules

Answer 30

Macrophage Dendritic cells B cells Activated T cells

Question 31

Cells produce IFN-alpha

Answer 31

Fibroblasts

Question 32

Methods to determine the degree of histocompatibility between donor and recipient

Answer 32

MHC matching Mixed lymphocyte culture (MLC)

Question 33

Critical cytokines that influence lineage maturation

Answer 33

Granulocyte-macrophage colony stimukating factor (GM-CSF) Interleukin 1 (IL-1) Erythropoietin

Question 34

Climical use of GM-CSF

Answer 34

Decrease infection in neutropenic patients

Question 35

2ndary lymphoid organs

Answer 35

Spleen Peripheral lymph nodes Skin Peyer's patches

Question 36

Required for lymphocyte to become sensitized

Answer 36

Accessory antigen-presenting cell (APC) or monocyte-macrophage line

Question 37

It amplifies the immune response by exerting an autocrine feedback on the same cell and a paraceine effect to activate other T cells in the local microenvironment

Answer 37

Function of IL-2

Question 38

ABO incompatibility Hyoersensitivity?

Answer 38

Type II

Question 39

Cells stimulated by Class II alloantigens

Answer 39

CD4 and T-helper cells

Question 40

Forms tubular transmembrane pores (once cytotoxic T cell binds to the antigen on the target cell) to allow unidirectional granule exocytosis with destruction of the target cell Released by sensitized T cells

Answer 40

Perforin

Question 41

Acts synergistically with IL-1 to mediate acute phase changes, including tumor necrosis, hypotension and inflammatory reactions

Answer 41

Effects of Tumor Necrosis Factor (TNF)

Question 42

Macrophage derived cytokines

Answer 42

IL-1, IL-6, and TNF-alpha

Question 43

Causes release of histamine from mast cells, is chemotactic for PMNs, has a kinin activity, and causes immune adhrence

Answer 43

C3a - biologic actions

Question 44

Factor initiates intrinsic pathway of clotting system

Answer 44

Hageman factor (factor XII)

Question 45

MOA of MYCOPHENOLATE MOFETIL

Answer 45

Blockade of purine synthesis in proliferating T cells with minimal effect on bone marrow

Question 46

Stage(s) of the cells cycle is radiation most effective

Answer 46

The M and G2 phase Lymphocytes are also sensitive in the G0 phase

Question 47

MC cause of death in transplant recipients

Answer 47

Infection Candida albicans then Aspergilus Viral - herpes group DNA (CMV)

Question 48

Vaccines should be given before elective splenectomy

Answer 48

H. Flu Meningococcus S. Pneumonia Given 1week before sx

Question 49

Marker of hepatocellular carcinoma

Answer 49

Alpha fetoprotein

Question 50

Why is left kidney preferred for donor nephrectomy

Answer 50

Longer left renal vein