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BOARD REVIEW > Medical Onco, Hema And Coag > Flashcards

Medical Onco, Hema And Coag Flashcards

1
Q

To which platelet glycoprotein does Vol Willebrand factor bind to enhance platelet aggregation

A

Glycoprotein Ib

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2
Q

Fibrinogen forms BRIDGES between activated platelets by binding to which platelet glycoprotein

A

Glycoprotein IIb/IIIa

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3
Q

Chromosomal abnormality in Burkitt’s lymphoma

A

Chromosomal translocation (8:14)

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4
Q

Neoplasm associated with Beta-napthylamine

A

Bladder cancer

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5
Q

Activated factor X (Xa), in combination with which 2 cofactors, activates prothrombin on the surface of platelets

A

Ionized calcium
Factor Va

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6
Q

Complex activates protein C on the surface of endothelial cells

A

Thrombin-thrombomodulin complex

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7
Q

Most central natural anticoagulant protein

A

Antithrombin III

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8
Q

Major endogenous activators of plasminogen

A

Tissue plasminogen activator (tPA) and
Urokinase

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9
Q

Prevents the reduction of Vit K once it has functioned as a cofactor for carboxylation of factor II, VII, IX and X

A

Sodium warfarin (Coumadin) as an anticoagulant

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10
Q

MC lab abnormality associated with antiphospholipid syndrome

A

Elevated aPTT not corrected by normal plasma

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11
Q

Laboratory test of hemophilia A

A

Prolongation of aPTT

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12
Q

Molecular abnormality in hemophilia B

A

X-linked recessive deficiency of factor IX (Christmas Factor)

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13
Q

MOA of METHOTREXATE

A

Binds dihydrofolate reductase, preventing reduction of folate to tetrahydrofolate, which is necessary for production of thymidine purines

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14
Q

Best tumor marker for choriocarcinoma

A

Beta-hCG

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15
Q

MOA of PACLITAXEL

A

Enhancement of tubulin polymerization

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16
Q

Drug usually associated with hemolytic uremic syndrome

A

Mitomycin C

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17
Q

Factors shift the oxygen curve to the RIGHT

A

High CO2
Low pH (Acidosis)
High DPG
High Temp

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18
Q

Only clotting factor NOT made in liver

A

Factor 8

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19
Q

Clotting abnormalities in Von Willibbrand disease

A

Long PTT and long bleeding time or functional platelet assay

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20
Q

Drug tx for Gestational trophoblastic neoplasm

A

Actinomycin D
MOA: blocks RNA synthesis by intercalating DNA nucleotide pairs

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21
Q

Most significant side effect associated with BLEOMYCIN

A

Interstitial pneumonitis

22
Q

Most important factor in predicting efficacy of progestin therapy in endometrial cancer

A

Progesterone receptor status of tumor

23
Q

Finding in peripheral blood smear characteristic of surgical or functional splenectomy

A

Howell-jolly bodies

24
Q

Storage form of iron

A

Ferritin

25
Q

Hemolytic anemia associated with ulcerative colitis

A

Autoimmune hemolytic anemia

26
Q

A graft placed in the anatomic position normally occupied by such tissue

A

Orthotopic graft

27
Q

Chromosome contains the Major Histocompatibility Complex (MHC)

A

Chromosome 6

28
Q

MHC antigens bets trigger the proliferation of allogenic lymphocytes

A

HLA class II antigen (HLA-D, DR, DQ, and DW/DR)

29
Q

Cells that have HLA Class I molecules

A

All nucleated cells

30
Q

Cells that have HLA Class II molecules

A

Macrophage
Dendritic cells
B cells
Activated T cells

31
Q

Cells produce IFN-alpha

A

Fibroblasts

32
Q

Methods to determine the degree of histocompatibility between donor and recipient

A

MHC matching
Mixed lymphocyte culture (MLC)

33
Q

Critical cytokines that influence lineage maturation

A

Granulocyte-macrophage colony stimukating factor (GM-CSF)
Interleukin 1 (IL-1)
Erythropoietin

34
Q

Climical use of GM-CSF

A

Decrease infection in neutropenic patients

35
Q

2ndary lymphoid organs

A

Spleen
Peripheral lymph nodes
Skin
Peyer’s patches

36
Q

Required for lymphocyte to become sensitized

A

Accessory antigen-presenting cell (APC) or monocyte-macrophage line

37
Q

It amplifies the immune response by exerting an autocrine feedback on the same cell and a paraceine effect to activate other T cells in the local microenvironment

A

Function of IL-2

38
Q

ABO incompatibility
Hyoersensitivity?

A

Type II

39
Q

Cells stimulated by Class II alloantigens

A

CD4 and T-helper cells

40
Q

Forms tubular transmembrane pores (once cytotoxic T cell binds to the antigen on the target cell) to allow unidirectional granule exocytosis with destruction of the target cell

Released by sensitized T cells

A

Perforin

41
Q

Acts synergistically with IL-1 to mediate acute phase changes, including tumor necrosis, hypotension and inflammatory reactions

A

Effects of Tumor Necrosis Factor (TNF)

42
Q

Macrophage derived cytokines

A

IL-1, IL-6, and TNF-alpha

43
Q

Causes release of histamine from mast cells, is chemotactic for PMNs, has a kinin activity, and causes immune adhrence

A

C3a - biologic actions

44
Q

Factor initiates intrinsic pathway of clotting system

A

Hageman factor (factor XII)

45
Q

MOA of MYCOPHENOLATE MOFETIL

A

Blockade of purine synthesis in proliferating T cells with minimal effect on bone marrow

46
Q

Stage(s) of the cells cycle is radiation most effective

A

The M and G2 phase
Lymphocytes are also sensitive in the G0 phase

47
Q

MC cause of death in transplant recipients

A

Infection
Candida albicans then Aspergilus
Viral - herpes group DNA (CMV)

48
Q

Vaccines should be given before elective splenectomy

A

H. Flu
Meningococcus
S. Pneumonia

Given 1week before sx

49
Q

Marker of hepatocellular carcinoma

A

Alpha fetoprotein

50
Q

Why is left kidney preferred for donor nephrectomy

A

Longer left renal vein

BOARD REVIEW (19 decks)

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