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endo II exam1 > MEN > Flashcards

MEN Flashcards

1
Q

MEN 1 wermer syndrome

A

pituitary adenoma
PTH hyperplasia
Pancreatic tumors

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2
Q

MEN2A

A

PTH hyperplasia
Medullary thyroid carcinoma
Pheochromocytoma

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3
Q

MEN2B

A

mucosal neuromas
marfanoid body habitus
medullary thyroid carcinoma
pheochromocytoma

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4
Q

tumors of MEN syndromes are usually what

A

multifocal and arise in multiple organs

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5
Q

MEN tumors preceded by

A

asymptomatic stage of hyperplasia in cell of origin

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6
Q

what type of hyerplasia would you expect before medullary thyroid carcinoma

A

C cell hyperplasia in thyroid parenchyma

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7
Q

most common manifestation of MEN-1

A

primary hyperPTH

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8
Q

leading cause of morbidity and mortality in persons with MEN1

A

endocrine tumors of the pancreas

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9
Q

most common secreted product from pancreatic tumor in MEN 1

A

pancreatic polypeptide

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10
Q

most common ant pituitary tumor with MEN1

A

PRLoma

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11
Q

msot common site gastrinomas in individuals with MEN1

A

duodenum

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12
Q

mutation in MEN1

A

germline MEN1 tumor suppressor gene which encodes menin

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13
Q

dominant clinical manifestations MEN1

A

hypoglycemia,, pepetic ulcers, nephrolithiasis from PTH hyperCa and PRL excess Sx

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14
Q

3 classes of MEN2

A

2A 2B and familial medullary thyroid cancer

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15
Q

how do we detect medullary thyroid Ca

A

increased calcitonin levels

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16
Q

test for pheochromcytomas

A

increased urinary metanephrines

17
Q

Mutation in sipple syndrome ( MEN2A

A

germline gain of function in RET proto-oncogene on chrom 10q11.2

18
Q

which MEN syndrome has the more aggressive medullary thyroid carcinomas and pheos

A

MEN 2B

19
Q

hyper PTH is not present in what MEN syndrome

A

2B

20
Q

familial medullary thyroid cancer is a variant of what MEn syndrome

A

2A

21
Q

individuals with RET mutations are advised to undergo what

A

prophylactic thyroidectomy to prevent formation of medullary carcinoma

endo II exam1 (14 decks)

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