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Flashcards in Metabolism, Enzymes Deck (76)
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1

Metabolism in Mitochondria

1. Fatty acid oxidation (β-oxidation)
2. Acetyl-CoA production
3. TCA
4. Oxidative phosphorylation
5. ketogenesis

2

Cytoplasm metalbolism

1. Protein synthesis (RER)
2. Glycolysis
3. Fatty acid synthesis
4. Steroid synthesis (SER)
5. Cholesterol synthesis
6. HMP shunt

3

Metabolism in both cytoplasm and mitochondria

1. Urea cycle
2. Heme synthesis
3. Gluconeogenesis

4

Kinases

Enzyme that uses ATP to add high energy phosphate group onto substrate

5

Phosphorylase

Enzyme that adds inorganic phosphate onto substrate without ATP

5

Dehydrogenase

Catalyzes oxidation-reduction reactions (pyruvate dehydrogenase)

6

Phosphatese

Enzyme that removes phosphate group from substrate

7

Hydroxylase

Adds hydroxyl group (-OH) onto substrate

9

Carboxylase

Transfer CO2 groups with the help of biotin

9

Site of HMP shunt

Cytoplasma

10

Mutase

Relocates a functional group within a molecule (vit b12 dependent methylmalonyl coa mutase)

11

Site of heme synthesis

Both cytoplasm and mitochondria

12

Acetyl coa production site

Mitochondria

13

Urea cycle site

Both cytoplasm and mitochondria

14

Gluconeogenesis

Both mitochondria and cytoplasm

15

Rate-determining enzyme of glycolysis

Phosphofructokinase-1 (PFK-1)

16

Rate-determining enzyme of gluconeogenesis

Fructose-1,6-bisphosphate

17

Rate-determining enzyme oF TCA

Isocitrate dehydrogenase

18

Rate-determining enzyme of glycogenesis

Glycogen synthase

19

Rate-determining enzyme of glycogenolysis

Glycogen phosphorylase

20

Rate-determining enzyme of HMP shunt

Glucose 6 phosphate dehydrogenase (G6PD)

21

Rate-determining enzyme of De novo pyrimidine synthesis

Carbamoyl phosphate synthetase II

22

Rate-determining enzyme of De novo purine synthesis

Glutamine - PRPP - amidotransferase

23

Rate-determining enzyme of Urea cycle

Carbamoyl phosphate synthetase I

24

Rate-determining enzyme of fatty acid synthesis

Acetyl coa carboxylase

25

Rate-determining enzyme of fatty acid oxidation

Carnitine acyltransferase I

26

Rate-determining enzyme of ketogenesis

HMG-Coa synthase

27

Rate-determining enzyme of Cholesterol synthesis

HMG-Coa reductase

29

Rte-determining enzymes of metabolic processes - means

Irreversible

29

Phosphorofructokinase regulators

AMP+ ATP- Citrate- Fructose-2,6-biphosphate +