Metoclopramide

Question 1

What is the brand/trade name for metoclopramide?

Answer 1

• Reglan

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
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Question 2

What is the pharmacologic category/class of metoclopramide?

Answer 2

• Dopamine antagonist
• Prokinetic
• Antiemetic

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}

Question 3

What is the mechanism of action of metoclopramide?

Answer 3

• Antiemetic: blocks dopamine receptors in the CTZ and vomitting center
• Prokinetic: enhances response to acetylcholine in the upper GI tract

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}

Question 4

What is the dose and of metoclopramide and when should it be given?

Answer 4

• Aspiration prophylaxis: 10-20 mg ~30 minutes before induction
• PONV prophylaxis/treatment: 10-20 mg near the end of surgery

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}

Question 5

What is the onset of action for metoclopramide?

Answer 5

• 1-3 minutes, peak in 1-2 hours

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}

Question 6

What is the duration of action for metoclopramide?

Answer 6

• 1-2 hours

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}

Question 7

The use of metoclopramide and other dopamine antagonists should be avoid in patients with ____________

Answer 7

• Parkinson’s disease

Risk for causing or worsening extrapyramidal symptoms

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Metoclopramide: Drug Information}