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Pharmacology - Antibiotics > Metronidazole > Flashcards

Metronidazole Flashcards

1
Q

Drug class?

A

Anaerobic antimicrobial

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2
Q

How does it work?

A
  • Bactericidal Abx
  • Broken down to toxic compounds within microbes with anaerobic/microaerophillic metabolism
  • Toxic compounds kill microbes by interfering with nucleic acid function and synthesis

Spectrum = Anaerobes (clostridia, bacteriodes etc.) and protozoa. Trichomonas, entamoeba histolytica, giardia lamblia, balantidium coli.

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3
Q

Indications?

A

Stuff infected with anaerobes.

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4
Q

Contra-indications?

A

Caution: pregnancy, breastfeeding, hepatic impairment

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5
Q

Side-effects?

A

Common: nausea, vomiting, anorexia, diarrhoea
Rarely: anaphylaxis, drowsiness, headache, dizziness, metallic taste in mouth

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6
Q

Possible interactions?

A

P450 INHIBITOR

  • Alcohol: causes disulfiram-like reaction (flushing, adbo pain, hypotension)
  • Phenytoin:  plasma conc of phenytoin by inhibiting metabolism
  • Warfarin:  anticoagulant effect by inhibiting metabolism
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Pharmacology - Antibiotics (8 decks)

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