MHC Complex Flashcards
(32 cards)
What T cells are able to recognize MHC I?
CTL
What T cells are able to recognize MHC II?
Th1, Th2, Th17, Tfh, Treg
What notable costimulatory molecules do Dendritic cells produce, along with MHCII?
B7 (CD80, CD86)
What activated B cells to produce costimulatory molecules?
Antigen binding to antibody
What activates macrophages to express MHC II and costimulatory molecules?
phagocytosis
What two characteristics make T cell receptors like antibodies?
Constant and variable portion of receptor
Consist of VDJ recombination
What do antibodies do in their differentiation that T cell receptors dont?
Somatic hypermutation
When an antigen binds to a T cell, what transmits the signal to the cell to differentiate?
CD3
What two signals are needed for a T cell to differentiate?
CD3 transmission and Cytokines from a dendritic cell
What signal transduction molecule does CD4 bind to?
p56lck
Is CD4 a monomer, dimer, trimer, or tetramer?
monomer
Is CD8 a monomer, dimer, trimer, or tetramer?
heterodimer or homodimer
What complex of differentiation on T cells binds to B7 on dendritic cells?
CD28
After CD28 binds B7, what is the pathway that is activated?
MAP kinase
What does CD2 bind?
LFA-3
What does LFA-1 bind?
ICAM (intracellular adhesion molecule)
What does CD45R bind?
CD22
Which chain (alpha or beta) is encoded by VJC genes?
alpha
What chain (alpha or beta) is encoded by the VDJC segments?
beta
What proteins are useful in DNA gene rearrangement during cell maturation?
RAG1 and 2
If T cells had AID in their gene expression, what would likely be the following pathology?
Autoimmunity
What molecules are included on MHC class III?
Complement, TNFa TNFb, heat shock proteins, etc
What peptide does every MHC-I molecule associate with on the cellular surface?
Beta2 macroglobulin
What are the three genes encoding MHCII?
DP encoding DP ab
DQ encoding DQ ab
DR encoding DR ab
