Microbio Exam 4 Flashcards by Jake S

What does B19 Cause?

erythema infectiosum

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What is the squamous epithelial growth that is either a wort or a verruca?

Papilloma

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What variant of hepatitis needs assistance form HBV, and therefore cannot work if you’re vaccinated?

HDV

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What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis E?

Abbreviation - HEV
Family Name - Hepeviridae
Nucleic Acid - RNA
Coating - Naked
Transmission - FO (Fecal Oral?)

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What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis D?

Abbreviation - HDV
Family name - Unassigned (No family name)
Nucleic Acid - RNA
Coating - ENV
Transmission - blood/sex

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What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis C?

Abbreviation - HCV
Family Name - Flaviviridae
Nucleic Acid - RNA
Coating - Envelope
Transmission - Blood/sex

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What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis B?

Abbreviation - HBV
Family Name - Hepadnaviridae
Nucleic Acid - DNA
Coating- Envelope
Transmission- Blood/sex

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What is the abbreviation, family name, nucleic acid, coating, and transmission of Hepatitis A?

Abbreviation - HAV
Family Name - Picornaviridae
Nucleic Acid - RNA
Coating - Naked
Transmission - FO

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What causes a yellow tinge in skin and eyes

Jaundice

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This is an inflammatory disease of liver cells that may result from infection by several viruses

Hepatitis

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Malignancy of Epithelial cells is?

nasopharyngeal carcinoma

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B cell malignancy is?

Burkitt Lymphoma

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Infectious mononucleosis is dormant where?

B Cells

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Sore throat, high fever, cervical lymph lymphadenopathy that develops after a 30-50 day incubation period is called?

Infectious mononucleosis

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What is the primary infection of V2V

Varicella (chickenpox)

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Humans as the only natural host, with infection transmitted by respiratory droplets and contact is called what?

Varicella - Zoster virus

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What causes inflammation of the eye, latent virus that travels into the ophthalmic rather than the mandibular branch of trigeminal nerve?

Herpetic Keratitis

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What is inflammation of the oral mucosa, especially in young children?

herpetic gingivostomatitis

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What is the most common recurrent HSV-1 Infection?

Herpes labials

otherwise known as cold sores

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What causes lesions on the genitalia, possibly oral - Occurs in the ages of 14-29 and can be spread without visible lesions?

HSV-2

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What causes lesions on the oropharynx, cold sores, fever blisters, and usually only occurs in early childhood?

HSV-1

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What was implicated in Kaposi sarcoma?

Herpesvirus 8 (KSHV)

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Roseola is

Human herpesviruses 6 and 7

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Cytomegalovirus (CMV) that infects the salivary glands and other viscera is

Herpesvirus 5

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The Epstein-barr virus (EBV) associated with infection of the lymphoid tissue is called?

Herpesvirus 4

The varicella-zoster virus (V2V) Chickenpox and shingles

Herpesvirus 3

Fever blisters and genital infections caused by which herpes variant?

Herpes Simplex 1 and 2 (HSV)

What is the genus of virus that all show latency and cause recurrent infection?

Herpesviruses

What is the common transmission route for smallpox?

Respiratory

What is the first disease to be eliminated by vaccination?

Smallpox

What produces eruptive skin pustules that leave scars

Pox

What is it called when a virus crosses placenta and affects the fetus?

Teratogenic

What is a virus that causes cancer called

oncogenic

What are the enveloped RNA viruses (Note: There are a LOOOOOOOT of them)

ORTHOMYXOVIRIDAE BUNYAVIRIDAE ARENAVIRIDAE PARAMYXOVIRIDAE RHABDOVIRIDAE FILOVIRIDAE CORONAVIRIDAE TOGAVIRIDAE FLAVIVIRIDAE RETROVIRIDAE

What are the naked RNA viruses? (Matching, there are 4)

Picornaviridae Caliciviridae Hepeviridae Reoviridae

What are the naked DNA viruses?(there are 3)

Adenoviridae Papillomaviridae Parvoviridae

What are the envelope DNA viruses? (Only two)

Poxviridae Herpesviridae

variola major last date and location was

75, bangladesh (south asia)

variola minor last date and location was

77, Somalia (East africa)

Edward Jenner is matched to

cowpox, smallpox

HPV-16 and HPV-18 was linked to what scientist

Harald zur Hausen

What virus causes hydrous fetalis

B19

Orthomyxoviridae is

h influenza virus

Bunyaviridae is

h hantavirus

Arenaviridae is

h lassa Fever virus

The 15 substypes that are the most important virulence factors that bind to host cells is called

Hemaglutnin

9 Subtypes - Hydrolyzes mucus and assists viral budding and release

neuraminidase

What is the difference between antigenic drift and antigenic shift

Drift is a minor change, Shift is a major change

What is the most virulent influenza

Influenzae A

What is the transmission by insects and tics

Bunyaviruses

American bunyavirus is a ________

hantavirus, Sin Nombre (no name)

Arenaviridae is

Lassa fever | Argentine hemorrhagic fever, Bolivian hemorrhagic fever etc ## Footnote Closely associated with rodent host Transmission through aerosols and contact

What are the enveloped nonsegmental ssRNA viruses

Paramyxoviruses Rhabdoviruses Coronaviruses Togaviruses Flaviviruses Filoviruses

What are mumps caused by

Mumps virus

Measles is also known as

Red measles and/or rubeola

Rabies is transmitted via

rabid animal biting you

What do people look for in people who die from rabies?

Negri bodies

What disease causes Kolpik's spots?

Measles

For the vector matching on exam 4, the answer is

Mosquito (professor admitted to fucking up and making all of the answers mosquito)

There's a _______ for hepatitis B, but not for hepatitis C

vaccine

With symptoms very similar to infection with the chikungunya virus or dengue viruses, this cause birth defects

Zika viruses

What fever causes Jaundice?

Yellow fever

What fever is nicknamed "breakbone" fever, and makes you feel like your bones are breaking?

Dengue fever

Marburg (1967) is where what virus was discovered?

Marburg virus

Filoviridae virus marburg and ebola virus are

BSL-4

What are the five species of ebolavirus?

Zaire Sudan Bundibugyo Tai forest Reston

HIV classification

Family - Retroviridae Genus - Lentivirus Species - Human immunodeficiency virus Types - HIV-1 (worldwide) and HIV-2 (only small parts of west Africa). HIV-2 is less transmissible and reduced likelihood to progress to AIDs.

What are the three enzymes of HIV

Reverse transcriptase Integrase Protease

What is the virion structure of HIV?

Enveloped RNA Icosahedral 72 spikes

What are the transmissions of HIV

Sex Blood Perinatal transmission - Placenta 25% - Birth 50% - Breast milk 25% Parentheral

What is the pathogenesis of HIV?

Helper T cells Macrophages Monocytes B cells Microglial brain cells Intestinal cells Suppression of cell-mediated immunity Opportunistic infection

What are the 3 stages of infection for HIV?

ACUTE - 2-4 weeks, mononucleosis like symptoms Latent - 7 to 11 year, asymptomatic Late - Decrease in CD4 cells to below 400/ul AIDs is when CD4 cells fall below to 200/ul

What does the treatment for HIV target?

Targets viral replication

What are the nonenveloped nonsegmental ssRNA viruses(there are 4)

Picornaviruses Enterovirus Rhinovirus Cardiovirus

What is the acute enteroviral infection of the spinal cord that can cause neuromuscular paralysis (although it is quite rare)

Poliomyelitis

Hepatitis A is transmitted how?

Fecal-Oral

Norwalk agent best known, believed to cause 1/3rd of all viral gastroenteritis cases and is transmitted by fecal-oral is called?

Caliciviruses

What unusual double stranded RNA genome is transmitted oral-fecal transmission, and is the primary viral cause of mortality and morbidity resulting from diarrhea in infants and children?

Rotavirus

What are the proteinaceous infetious particles that are highly resistant to multiple forms of treatment?

Prions

Who was the scientist that created the smallpox vaccination (also potentially child abuser)

Edward Jenner

Who won the nobel piece prize for discovering the link between HPV and cancer?

Harald Zur Hausen

Clara maass is

The only woman volunteer who died after experimental mosquito exposure and developed severe yellow fever. Her death led to a public outcry that ended human experimentation.

Mikhail Surenovich Balayan is

Russian virologist who incubated feces in yogurt and ate it like a weirdo, incubating HEV in his body.

Who discovered prions

Stanley B. Prusiner

HHV-1 Is ______ and causes _______

Herpes Simplex 1, usually lesions on the oropharynx, cold sores, fever blisters. Occurs in early childhood.

HHV-2 is ________ and causes _______

Herpes Simplex 2 , Lesions on the genitalia, possibly oral. Occurs in ages 14-29, can be spread without visible lesions.

HHV-3 Is ____ and causes ______

Varicella zoster - Causes chickenpox and can be reactivated as shingles.

HHV-4 Is ______ and causes ______

Epstein-Barr, causes mono/kissing disease. Transmitted through direct, oral contact and contamination with saliva.

HHV-5 is _____ and causes _____

Cytomegalovirus - Produces giant cells with nuclear and cytoplasmic inclusions. Transmitted through saliva, respiratory mucus, milk, urine, semen, cervical secretions etc. Causes fever, fatigue.

HHV-8 Is _______ and causes ______

Kaposi's sarcoma-Associated virus (KSHV), linked with common tumor of AIDs patients; also may be involved in multiple myeloma

(Matching) Name all the Env DNA. (there's a lot, dont get discouraged missing some)

POXVIRIDAE *smallpox *cowpox *monkeypox *Molluscum contagiosum HERPESVIRIDAE *HHV-1 through 8 HEPADANIVIRIDAE *HBV

(Matching) Name all the naked DNA

ADENOVIRIDAE PAPILLOMAVIRIDAE *HPV 1-4 *HPV6, 11 *HPV 16, 18 PARVOVIRIDAE *B19

(Matching) Name all the naked RNA.

PICORNAVIRIDAE *Polio *HAV *Rhinovirus CALCIVIRIDAE *Norovirus HEPEVIRIDAE *HEV REOVIRIDAE RotaVirus

(Matching) Name all the Enveloped RNA viruses

ORTHOMYXOVIRIDAE *Influenza A, B, C BUNYAVIRIDAE *Hantavirus ARENAVIRIDAE *lassa fever PARAMYXOVIRIDAE *parainfluenza *Mumps *Measles *RSV RHABDOVIRIDAE *Rabies FILOVIRIDAE *Marburg *Ebola CORONAVIRIDAE Coronavirus* SARS* MERS* TOGAVIRIDAE *Rubella FLAVIVIRIDAE *HCV *Yellow Fever *Dengue Fever *west Nile *Zika RETROVIRIDAE *HIV

A constant mutation is called ________ that gradually changes their amino acid composition

Antigenic Drift

one of the genes or RNA strands is substituted with a gene or strand from another influenza virus from a different animal host is called _________

Antigenic Shift

Where do pox viruses replicate?

In the Cytoplasm

Most common Route for smallpox is

Respiratory

What is the much more common poxvirus that causes a skin disease?

molluscum contagiosum

What's the only available vaccine for HPV in the united states?

Gardisal 9

Harald Zur hausen is matched with which HPV?

HPV-16 and 18

Parainfluenza is transmitted by

Respiratory

What is the self-limited illness associated with painful swelling of parotid salivary glands?

Epidemic parotitis

What are the oral lesions associated with measles?

Koplik's Spots

What is the initial testing for HIV?

ELISA (Enzyme linked immunoabsorbant assay)

What is the confirmatory testing for HIV?

Western blot

transmissible spongiform encephalopathies (TSEs) in humans, Creutzfeldt-Jakob disease (CJD) are the two _______ diseases

Prions

Prion is short for

Protein Infection

Who is the scientist that won a Nobel prize for discovering prions?

Stanley B Prusiner.

list all the diseases transmitted from sex

Hepadnaviridae (HBV/Hepatitis B) Flaviviridae (HCV/Hepatitis C) HDV (Hepatitis D) HIV/Retroviridae HHV-2 Molluscum Contagiosum

List all the diseases transmitted from vectors

Flaviviridae -West Nile virus -yellow fever virus -Dengue fever virus -Zika virus

List all the diseases transmitted from Fecal/Oral

-Picornaviridae (HAV/Hepatitis A) -Hepeviridae (HEV/Hepatitis E) -Adenoviridae (gastroenteritis) -Picornaviridae (HAV, poliovirus)

List all the diseases transmitted from respiratory

Smallpox (Poxviridae) Chickenpox (HHV-3) Adenoviridae (respiratory infections) Parvoviridae Coronaviridae Togaviridae Paramyxoviridae (parainfluenza, mumps, measles, pneumonia and bronchitis) Orthomyxoviridae Bunyaviridae

List all the disease transmitted from ingestion

Any prion disease

Microbio Exam 4 Flashcards

To study for Exam 4 of Micro (114 cards)