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Flashcards in misc Deck (41):
1

chromosome 3 (2)

VHL, renal cell carcinoma

2

chromosome 4 (1)

Huntington's

3

chromosome 5 (2)

APC, Cri-du-chat

4

chromosome 7 (2)

CFTR, Williams

5

chromosome 9 (1)

F. ataxia

6

chromosome 11 (1)

WT1/2

7

chromosome 15 (2)

Prader-Willi/Angelman

8

chromosome 16 (1)

ADPKD

9

chromosome 17 (2)

NF1, P53

10

TGF beta

growth factor for tissue repair/regeneration

11

baclofen

MOA: inhibits GABA at spinal level, inducing relaxation
USE: muscle spasm

12

cyclobenzaprine

MOA: centrally acting skeletal mm. relaxant, structurally similar to TCAs
USE: mm. spasm

13

bile acid resins (cholestyramine)

prevent intestinal reabsorption of bile acids so liver must use cholesterol to make more
ADR: chol gallstones, pts. don't like it

14

niacin

MOA: inhibits lipolysis in adipose tissue, reduces hepatic VLDL synthesis
ADR: flushing (aspirin), hyperglycemia (may need to adjust DM meds), hyperuricemia

15

ezetimibe

MOA: prevent cholesterol absorption at small intestine brush border

16

fibrates

MOA: upregulate LPL to increase TG clearance; activates PPAR to induce HDL synthesis
ADR: chol gallstones, myositis with statins

17

anti-cardiolipin

SLE, antiphospholipid syndrome

18

anticentromere

CREST syndrome

19

anti-desmoglein

pemphigus vulgaris

20

anti-Smith

SLE

21

anti-glutamate decarboxylase

T1DM

22

antihistone

drug-induced lupus

23

antibodies in poly/dermatomyositis

anti-Jo-1, anti-SRP, anti-Mi-2

24

antimicrosomal

Hashimoto

25

anti-Scl-70

scleroderma (diffuse)

26

anti-smooth muscle

autoimmune hepatitis

27

anti-SSA, anti-SSB

Sjogren (anti-Ro, anti-La)

28

anti-TSH

Graves

29

IgA antiendomysial, IgA anti-tissue

Celiac disease

30

anti-CCP

RA (also rheumatoid factor)

31

theophylline

MOA: bronchodilation by inhibiting phosphodiesterase (increase cAMP)
- blocks action of adenosine
ADR: cardiotoxicity, neurotoxicity

32

ipratropium

MOA: prevents bronchoconstriction; muscarinic antagonist
USE: asthma, COPD

33

beclomethasone, fluticasone

MOA: corticosteroids, inhibits cytokine synthesis

34

montelukast, zafirlukast

MOA: block leukotriene receptors
USE: aspirin-induced asthma

35

zileuton

MOA: lipoxygenase pathway inhibitor, blocks synthesis of leukotrienes
USE: asthma

36

bosentan

MOA: antagonist of endothelia-1 receptors to decrease pulmonary vascular resistance
USE: pulmonary arterial hypertension

37

clindamycin

blocks peptide transfer at 50S
USE: anaerobes below diaphragm
ADR: pseudomembranous colitis

38

shock types

hypovolemic/cardiogenic: low-output failure, vasoconstriction
distributive (septic): high-output failure, vasodilation (warm, dry)

39

I cell disease

defect in phosphotransferase so golgi doesn't phosphorylate mannose residues: proteins secreted extracellularly instead of to lysosomes
- coarse features, clouded corneas, restricted joint movement, high plasma levels of lysosomal enzymes

40

Hb conformation

T in Tissues (low O2 affinity)
R in Respiratory tract

41

pacinian vs. meissner corpuscles

pacinian: pressure, vibration
meissner: fine/light touch