MISSED PHARM

Question 1

chemotherapy for hodgkin’s lymphoma

Answer 1

Procarbazine –> DISULFIRAM RXN

Question 2

TB tx

Answer 2

Isoniazid –> DISULFIRAM RXN

Question 3

Tx for C diff, trich

Answer 3

metronidazole –> DISULFIRAM RXN

Question 4

cefotetan/cefoperazone cause

Answer 4

disulfiram reactions –> 2/3rd gen cephalosporins

Question 5

Hydralazine: safe in pregnancy, yes or no?

Answer 5

Yes

Question 6

1st line drug for trigeminal neuralgia

Answer 6

Carbamazepine

Question 7

Carbamazepine Side Effects

Answer 7

SIADH, aplastic anemia –> for trigem neuralgia

Question 8

Valproate given to pregnant woman

Answer 8

neural tube defects

Question 9

ACE inhibitors given to pregnant woman

Answer 9

Renal agenesis, oligohydramnios

Question 10

Warfarin given to pregnant woman

Answer 10

bone defects, hemorrhage

Question 11

aminoglycosides given to pregnant woman

Answer 11

Ototoxicity

Question 12

thalidomide given to pregnant woman

Answer 12

limb defects

Question 13

fluoruinolones are associated with

Answer 13

tendon rupture and QTC increase

Question 14

sulfonamides associated with

Answer 14

SJS, G6PD hemolysis

Question 15

Rifampin is associated with

Answer 15

red secretions

Question 16

Valproic acid is a broad spectrum

Answer 16

anticonvulsant and mood stabilizer that increases GABA
blocks NA
blocks Ca2+

Question 17

bipolar pt on meds, LFTs increased, abdominal pain

Answer 17

Valproate hepatotoxicity

Question 18

pregnant woman on antiepileptic, fetus with spina bifida

Answer 18

valproic acid

Question 19

Child with absence and tonic clonic seizures

Answer 19

valproic acid

Question 20

Pt on seizure med with tremor and weight gain

Answer 20

valproate side effects

Question 21

Mnemonic for VALPROATE

Answer 21

V = vomiting
A = Alopecia
L = Liver toxicity
P = pancreatitis
R = retardation
O = obesity
A = ataxia
T = tremor
E = enzyme inhibitor

Question 22

what is phenytoin?

Answer 22

antiepileptic drug used to treat seizures.

Question 23

MOA of phenytoin?

Answer 23

blocks voltage gated NA channels

Question 24

In fetus: wide spaced eyes, cleft palate, hypplastic nails, limb defects, developmental delays

Answer 24

Fetal Hydantoin syndrome from mom taking phenytoin for seizures. dont give in pregnancy

Question 25

Gingival overgrowth + seizure meds

Answer 25

Phenytoin

Question 26

Seizure pt with ataxia, diplopia, nystagmus

Answer 26

phenytoin toxicity

Question 27

taking seizure meds + warfarin stops working

Answer 27

Phenytoin = Cyp450 inducer (increases drug metabolism so other drugs are less effective)

Question 28

Gi distress, tinnitus, hyperthermia, tachypnea, resp alkalosis, met acidosis, and potential cardiovascular collapse is due to what toxicity?

Answer 28

Aspirin (salicylate toxicity)

Question 29

aspirin toxicity can lead to an overproduction of

Answer 29

proinflammatory leukotrienes and cause bronchospasm