Mix Day 3

Question 1

Anthracyclines (dunorubicin, doxorubicin, epirubicin, idarubicin) toxicity

Answer 1

Chemo drugs

• Generate free radicals => cardiotoxicity
• Dose-related dilated cardiomyopathy => LV&RVHF sx

Question 2

Maternal serum quadruple screen measures what?

Answer 2

• AFP
• Estriol
• beta-HCG
• Inhibin A

Question 3

Huntingtin protein CAG trinucleotide repeats causes a ______ of the gene?

Answer 3

Gain of function

• Prevents acetylation of histones => can’t transcribe shit
• Increased huntingtin expression => transcriptional silencing

Question 4

Anaplastic = ??

Answer 4

Undifferentiated

Question 5

Anaplastic tumors characteristics

Answer 5

No resemblance to tissue of origin

• Composed of pleomorphic cells w/ large hyperchromatic nuclei => grow in a disorganized fashion
• May also contain numerous, abnormal mitoses and giant tumor cells

Question 6

Intermittent diplopia, difficulty chewing, and speech problems

Answer 6

Myasthenia gravis

• IgG autoAb interference at NMJ
• Type II hypersensitivity

Question 7

Origin of teniae coli

Answer 7

Cecal base (also where the appendix is)

Question 8

Diphtheria toxoid is usually conjugated w/ which bug?

Answer 8

H flu

Question 9

Pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase require what?

Answer 9

Thiamine as a cofactor

- W/o thiamine => wernicke

Question 10

Persistent fever in kid, brassy cough, difficulty breathing, recent history of UPI - stridor on PE

Answer 10

Croup

• Aka laryngotracheitis
• Parainfluenza virus (paramyxovirus)