moa angina Flashcards
asa moa
MOA: irreversibly inhibits COX1 causing dec PG and thromboxane A2 so platelets don’t stick
Ranolazine moa
MOA: blocks Na from coming into the cell so Ca overload does not occur and coronary blood flow is improved
P2Y12 inhibitor prodrugs/irreversible
clopidogrel, prasugrel, ticlopidine
P2Y12 inhibitor not prodrugs/reversible
cangrelor, ticagrelor
Inhibits platelet aggregation faster than clopidogrel
prasugrel
Acts faster but not as long as clopidogrel or prasugrel
ticagrelor
Significant drug interactions with CYP3A4 inhibitors and inducers
tigagrelor
GPIIb/IIIa inhibitors moa
MOA: prevent fibrinogen from binding to glycoprotein IIb/IIIa receptors on platelets
what does fibrinogen do?
forms bridge between 2 platelets by binding to each glycoprotein IIb/IIIa sites
causes platelets to aggregate
cilostazol moa
MOA: selective inhibitors of PDE3; this causes cAMP to inc which then causes protein kinase A to inc (PKA) which inhibits platelet aggregation
Dipyridamole moa
MOA: inhibits reuptake of adenosine by RBC causing blood vessels to vasodilate; inhibits PDE 3 and PDE 5 which inc cAMP
Intrinsic pathway AKA _____ pathway
contact activation
Extrinsic pathway AKA______pathway
tissue factor
intricsic pathway deals with factor
12
extrinsic pathway deals with factor
7
PT- ______(8 letters +PT=10) (dont use PT anymore… use INR)
warfarin
aPTT- ______ (7 letters + PTT=10)
heparin
heparin moa
MOA: catalyzes antithrombin and inactivates thrombin which prevents conversion of fibrinogen to fibrin; inhibits factors 2a, 9a, 10a, 11a, and 12a
common pathway : factor ___
X
LMWH: Exoxaparin and dalteparin
moa
MOA: inhibits clotting factor 10a
LMWH: Exoxaparin and dalteparin
pregnancy
B
do we monitor LMWH: Exoxaparin and dalteparin
no
do we monitor heparin?
yes by PTT
warfarin moa
MOA: liver uses vitamin K to make clotting proteins. Warfarin is a vit K antagonist and depletes factors 2a, 7a, 9a, 10a (intrinsic and extrinsic pathway) and protein C and S which slows fibrin formation
warfarin preganncy
X
warfarin dosing
Start with maintenance dose of 5mg/day
Bridge therapy- giving heparin or LMWH before warfarin kicks in. warfarin takes 3-5 days to kick in so sometimes ppl need anticoag immediately and cant wait 3-5 days