Module 14

Question 1

What is the definition of Guillain-Barre Syndrome?

Answer 1

GBS, also referred to as acute inflammatory demyelinating polyneuropathy (AIDP) and Landry’s ascending paralysis, is an inflammatory disorder of the peripheral nerves.

Question 2

What is the Genetic/Gender/Age influence of GBS?

Answer 2

None

Question 3

What is the Prevalence of GBS?

Answer 3

Not reported

Question 4

What is the incidence of GBS?

Answer 4

5,000

Question 5

What is the mortality rate of GBS?

Answer 5

5%

Question 6

What is the cause of GBS/

Answer 6

An autoimmune disorder and 50% of all cases occur shortly after a viral or bacterial infection such as a sore throat or diarrhea.
Lymphocytic infiltration of spinal roots and peripheral nerves, followed by macrophage-mediated multifocal stripping of myelin, progressively impede electrical impulse propagation leading to flaccid paralysis.

Question 7

What is the pathophysiology of GBS?

Answer 7

lower motor neuron: rapid ascending weakness, bilateral sensory impairment, loss of reflexes, atrophy, fasciculations, muscle cramps.

Question 8

What is the diagnostic procedures of GBS?

Answer 8

nerve conduction test
lumbar puncture
stocking-and-glove sensory impairments: paint, hyperesthesia, parasthesias, numbness, and decreased proprioception

Question 9

What drug procedures is used for GBS?

Answer 9

Plasmapheresis

High Dosage Intravenous Immunoglobulin’s (IVIG)

Question 10

What is plasmapheresis?

Answer 10

removal of blood, separation of blood cells from plasma, and return of those blood cells to the body’s circulation, diluted with fresh plasma or a substitute.

Question 11

What is High Dosage Intravenous Immunoglobulin’s?

Answer 11

sterile solution of concentrated antibodies extracted from healthy donors and administered into a vein.