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Hematology II > MODULE > Flashcards

MODULE Flashcards

1
Q

In Vivo Coagulation

A

Tissue factor
Platelets

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2
Q

In Vitro Coagulation

A

Activation of Factor XII

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3
Q

Two phases of coagulation:

A

Initiation
Propagation

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4
Q

COAGULATION REGULATORY MECHANISMS

A

TAFI
PROTEIN C RUGULATORY SYSTEM

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5
Q

COAGULATION REGULATORY PROTEINS

A

Antithrombin
Heparin Cofactor II
Protein Z
Protein C inhibition

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6
Q

● clot dissolution to keep blood vessels free from deposited fibrin and fibrin clots
● occurs when plasminogen is converted to plasmin.
● if it occurs excessively, it can cause bleeding
● if it occurs inadequately, it can lead to thrombosis

A

FIBRINOLYSIS

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7
Q

Activators of Fibrinolysis

A

Tissue Plasminogen Activator
Urokinase Plasminogen Activated

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8
Q

occurs on tissue factor-expressing cells

A

Initiation

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9
Q

produces 3% - 5% of the total thrombin generated

A

Initiation

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10
Q

occurs on platelets

A

Propagation

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11
Q

produces 95% or more of the total thrombin generated

A

Propagation

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12
Q

principal regulator of the tissue factor pathway

A

TAFI

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13
Q

revises thrombin’s function from a procoagulant enzyme to an anticoagulant

A

Protein C regulatory system

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14
Q

first to be identified; inhibits Factor IIa, IXa, Xa, XIa, XIIa, PK, Plasmin

A

Antithrombin

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15
Q

inactivates thrombin

A

Heparin cofactor II

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16
Q

dependent protease inhibitor - potent inhibitor of Factor Xa; also inhibits Factor XIa

A

Protein Z

17
Q

inhibits APC, IIa, Xa, XIa, urokinase

A

Protein C inhibitor

18
Q

two glycosylated kringle regions

A

TPA

19
Q

the principal inhibitor of plasminogen activators TPA and UPA

A

PAI-1

20
Q

primary inhibitor of free plasmin

A

A2- antiplasmin

21
Q

becomes activated by the thrombin-thrombomodulin complex

A

Thrombin

22
Q

inhibits fibrinolysis by preventing the binding of TPA and plasminogen to fibrin, and blocking the formation of plasmin.

A

Thrombin

23
Q

D-E-D

A

Fragment X

24
Q

D-E

A

Fragment Y

Hematology II (16 decks)

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