Module 3 Lec 2

Question 1

What are 3 types of anemias that can decrease RBCs?

Answer 1

Iron-deficiency - blood loss or dietary deficiency

Folate and B12 deficiency (megaloblastic anemia) - ;ack of thymidine synthesis for DNA

antiproliferative drugs (aplastic anemia) - decrease normal hematopoietic activity. affects cell lineages

Question 2

what are some defenses erythrocytes have against ROS?

Answer 2

catalases and glutathione

Question 3

what can xenobiotics do to trigger an immune response against red blood cells?

Answer 3

act as a hapten by attaching to RBC surfaces

Question 4

what 3 things can xenobiotics affect erythrocytes?

Answer 4

Production, function, survival

Question 5

What is Erthrocytosis?

Answer 5

Excessive RBC circulation

Question 6

what is the 2 mechanisms of anemia when exposed to toxins?

Answer 6

Impaired RBC production
Destruction of RBCs

Question 7

What is hemolytic anemia?

Answer 7

When RBCs are destroyed by the immune system

Question 8

What is dangerous about methemoglobin and what can cause it?

Answer 8

changes RBC to become incapable of carrying O2
Can be caused by nitrate