Module 2 Lec 1

Question 1

define mechanistic toxicology

Answer 1

study of how chemical agents interact with living organisms to cause toxicity (mechanism of action)

Question 2

what are the 6 increasing levels of biological organization?

Answer 2

toxicant, macro-molecular interactions. cellular responses, organ responses, individual responses, population responses

Question 3

define adverse outcome pathway

Answer 3

a model identifying the sequence of biochemical events required to produce an adverse outcome when exposed to a substance

Question 4

in Adverse Outcome Pathways (AOP), what is the initiating event?

Answer 4

when an interaction between a toxin and organism takes place (i.e. binding)

Question 5

in Adverse Outcome Pathways (AOP), what is the key event?

Answer 5

the characterization of toxicity

Question 6

in Adverse Outcome Pathways (AOP), what are the adverse outcomes?

Answer 6

the disease or impairment occurring from exposure

Question 7

What would be the steps in examining how a toxin affects a pathway?

Answer 7

the Molecular initiating event
the cellular response
the organ’s response
the organisms response