mood disorder pt3+pt4

Question 1

what is 5-HT

Answer 1

Serotonin

Question 2

what is monoamine deficiency hypothesis

Answer 2

depression due to insufficient levels of monoamine NT: ie.
-serotonin (5-HT)
-norepinephrine
-dopamine

Question 3

how to measure serotonin level in human brain

Answer 3

The pet scan and tracer method works well on dopamine.
->new molecule with same affinity for the serotonin NT ​

Radioactive tracer injected and it binds to a specific target ​

Can measure how much of the tracer has binded to receptor -> work out receptor numbers​

A pharmaceutical challenge can be given to cause the release of neurotransmitters from the pre synaptic vesicles ​

Serotonin and tracer fight each other to bind to a receptor. More serotonin= more tracers kicked out ​

Question 4

what does a tracer do?

Answer 4

bind to a specific target- ie. receptor

Question 5

what method is used to measure serotonin level in human brain

Answer 5

PET scan and radioactive tracer injection.

Question 6

what tryptamine psychedelic effect and safety

Answer 6

effects:
-oceanic boundlessness: blissful state and spiritual experience.

safety:
-non-addictive, low brain toxicity
-dysphoria, nausea, headache

Question 7

what increases synapse monoamine conc/useful antidepressants

Answer 7

TCA-tricyclic antidepressants,
SSRI-selective serotonin reuptake inhibitor,
MAOI-monoamine oxidase inhibitor

Question 8

where does psychedelics bind to and give an example of a psychedelic

Answer 8

serotonin 2A receptor agonist.
-LSD///tryptamine