addiction tutorial

Question 1

define intoxication

Answer 1

transient syndrome due to recent substance ingestion, producing sig. psychological/physical impairment. Changes disappear when substance is elimated from body

Question 2

how to calculate alcohol units

Answer 2

(%strength x ml)/1000= units

Question 3

what is the excretion rate

Answer 3

1 unit (8g of pure alcohol) per hour

Question 4

alcohol intake advice

Answer 4

14 units per week spread across 3+ days

Question 5

metabolism of alcohol

Answer 5

ethanol is oxidised by alcohol dehydrogenase to acetaldehyde. acetaldehyde oxidise this to CO2+ H2O. in liver

Question 6

med to help alcohol abstinence and how

Answer 6

Acamprosate- increase GABA, NMDA antagonist

Question 7

detox regimes for alcohol and how

Answer 7

benzodiazepine- ie chlordiazepoxide

also give thiamine (B12) and folate

Question 8

med for abstinence for opioids

Answer 8

methadone - maintenance dose 60-120 mg daily

Question 9

detox regimes for opioids

Answer 9

maintenance treatment (ie methadone). 12months +. before reducing dose over several months

Question 10

abstinence for benzodiazepine dependence

Answer 10

maintenance on diazepam with reducing regime.

Question 11

detox regime for benzodiazepine dependence

Answer 11

baclofen (GABA agonist)