psychosis Flashcards

(29 cards)

1
Q

what is psychosis and examples

A

difficulty perceiving and interpreting reality

umbrella for many diseases, ie- schizophrenia, bipolar I, delusional disorder, drug induced etc

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2
Q

types of psychosis symptoms domain

A

positive

negative

disorganised

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3
Q

example of positive symptoms

A

hallucination-perception in absence of stimulus
-all 5 senses
-commonly auditory
-1st= though echo, 2nd, 3rd person running commentary/command hallucinations

delusions-fixed, false belief not in keeping with social/cultural norms.
-passive experience- thought are controlled by external agent. ie. thought broadcasting, insertion, withdrawal.

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4
Q

what are some negative symptoms

A

alogia
anhedonia
asociality-
avolition
apathy
affective flattening

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5
Q

what is alogia

A

decreased speech

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6
Q

what is anhedonia

A

inability to feel pleasure

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7
Q

what is
asociality-

A

being more alone

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8
Q

what is avolition

A

lack of motivation

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9
Q

what is apathy and affective flattening

A

apathy -lack of enthusiasm

affective flattening-reduced facial expression/body language, poor eye contact

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10
Q

examples of disorganised symptoms

A

-bizzare behaviour=
-aggression, agitation, inappropriate social behaviour

-formal though disorder- lack of logical connection between thoughts

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11
Q

psychosis onset, course, morbidity, mortality?

A

onset- commonly early 20s, (peak later in women)

course- chronic+ episodic

morbidity- impact QoL (risk heart disease)//impact education, employment

mortality-high risk of suicide

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12
Q

what is in the Mental state examination (MSE)

A

A Sailor Makes Tea, Pours Calmly, and Ignores

Appearance and behaviour
Speech
Mood and Affect
Thoughts
Perceptions
Cognition
Insight

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13
Q

psych hx for psychosis: HPC/Psych hx, fam hx, environemnt?

A

HPC: 6-18 months before has prodromal symptoms similar to depression

Psych Hx: increased risk if they had mental issues in the past

fam hx- important as schizophrenia=highly heritable. High concordance in MZ twins. Highly polygenic

environmental-drugs, ACE, prenatal/birth complication

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14
Q

Examples of prodromal symptoms in psychosis that’s often misdiagnosed in depression

A

-increasing isolation
-poor self care
-social withdrawal
-declining academic performance

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15
Q

what to look out for in MSE for psychosis - appearance and behaviour

A

appearance:
Bizarre or inappropriate clothing
Self-neglect
Self-harm injuries

behaviour:
eye-contact
unreactive
agitation
Abnormal movements

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16
Q

what to look for in speech compartment of MSE

A

Comment on rate/rhythm/volume

17
Q

description of thought disorder

A

circumstantial
tangential
flight of ideas
derailment
word salad

18
Q

what is pseudohallucination (vs hallucination

A

pseudohallucination:
-insight preserved
-ie voices perceived originating from inside head rather than outside

19
Q

what is tactile hallucination

A

involving sense of touch- ie ‘can feel chip inside his brain’

20
Q

What difficulties might you have treating someone with poor insight into their psychosis?

A

-consenting to treatment
-FU attendance
-willing to admit to hospital

21
Q

psychosis diagnosis?

A

can’t diagnose schizophrenia based from 1 psychotic episode.
-follow up for 3 years under Early Intervention of Psychosis Service

22
Q

management of psychosis

A

antipsychotic
CBT
social support

23
Q

antipsychotics in psychosis -2 types name of drug

A

dopamine antagonist-ie.risperidone
(but can also target NTs like serotonin, acetylcholine, histamine)

new partial agonist= aripiprazole

24
Q

describe dopamine activity in psychosis

A

Increased dopamine activity in mesolimbic dopamine system cause positive symptoms of psychosis

25
side effect of dopamine agonist vs antagonist
agonist- used in parkinson's disease can cause psychotic symptoms antagonist: parkinsonism
26
what are extrapyramidal side effects (EPSEs)- explain and give examples
Dopamine blockade in the nigrostriatal (extrapyramidal) dopamine system (parts of the brain that enable us to maintain posture and tone) Parkinsonism Acute dystonic reactions Tardive dyskinesia Akathisia
27
other side effects of antipsychotics
weight gain, increased prolactin, long QTc
28
management of EPSE
counsel about risk, use lowest therapeutic dose, first line= atypical
29
typical vs atypical drugs in antipsychotics what are they
typical- older - first generation atypical- newer- second generation -- associated with lower EPSE risk. Due to 5HT-2A antagonism