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BB 3rd Edition > Mouse basic biology/history > Flashcards

Mouse basic biology/history Flashcards

(54 cards)

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1
Q

Thymic maturation

A

Involutes around 35-80 days of ages

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2
Q

MALT

A

Contains more lymphoid cells and produces greater amount of immunoglobulin than both the spleen and LN

Peyer’s patches, cecal lymphoid tissue, lymphoid tissue in upper and lower respiratory system, as well as respiratory and genitourinary system

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3
Q

Vertebral formula - mouse

A

C7T13L6S4C28

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4
Q

Mammary glands - mouse

A

Five pairs - three cervicothoracic, two inguinoabdominal

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5
Q

Estrous cycle - mouse

A

Polyestrous, cycles every 4-5 days

Proestrus/estrus - active epithelial growth culminates in ovulation

Metestrus - degenerative epithelial changes

Diestrus - Quiescence/slow growth

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6
Q

Sex glands - male mouse

A

Ampullary gland, seminal vesicle, anterior/ventral/dorsal prostate, bulbourethral gland, preputial glands

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7
Q

Whitten effect

A

Re-entry into estrus synchronized in group housed females by exposure to pheromones in the male mouse urine. Within 3 days.

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8
Q

Bruce effect

A

Pheromones from a strange male mouse may prevent implantation or pseudopregnancy in recently bred females

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9
Q

Copulatory plug

A

Vesicular and coagulating gland secretions

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10
Q

Fertilization of ova

A

Can be fertilized for 10-12h after ovulation, takes place in the ampulla or upper portion of the oviduct

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11
Q

MUP20

A

Male-specific major urinary protein - rewarding and attractive to females, intermale agression/area avoidance

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12
Q

Male lacrimal protein ESP1

A

Lordosis in female mouse

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13
Q

Exocrine gland secreting peptide 22 (ESP22)

A

Inhibitory on older adult male mating behavior

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14
Q

Humoral immunity - mice

A

The majority of antibody is transferred through colostrum

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15
Q

Releaser pheromones

A

Elicit an immediate behavioral response

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16
Q

Primer pheromone

A

Mediate a slowly developing and longer-lasting endocrine response

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17
Q

Singaler pheromones

A

Convey individual or group indentity

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18
Q

Pheromone sensory organs

A

Vomeronasal organ, olfactory epithelium, septal organ of Masera, Gruenberg ganglion

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19
Q

Mups

A

Murine urinary proteins, chromosome 4, lipocalins, synthesized in liver

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20
Q

Kairomones

A

Chemical signals between species

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21
Q

Mus m 1

A

(Ag 1 or MA1), encoded by Mup 17 gene, potent allergen

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22
Q

Vandenbergh effect

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A

Acceleration of puberty in juvenile females in response to male urine

23
Q

Lee-Boot

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A

Group housed females that are isolated from males, suppression of estrus cyclicity

24
Q

Mouse puberty

25
Compensation for high metabolic rate
high alveolar PO2; a rapid respiratory rate; a short air passage; a moderately high erythrocyte (RBC) concentration; high RBC hemoglobin and carbonic anhydrase concentrations; a high blood O2 capacity; a slight shift in the O2-dissociation curve, enabling O2 to be unloaded in the tissue capillaries at a high PO2; a more pronounced Bohr effect, i.e., the hemoglobin affinity for O2 with changes in pH is more pronounced; a high capillary density; and a high blood sugar concentration.
26
Altered Schaedler's Flora
Four originals (two lactobacilli, Bacteroides distasonis, and EOS fusiform bacteria), a spiral-shaped bacterium, and three new fusiform EOS bacteria
27
Periarteriolar sheath in mice (spleen)
Mostly CD4+ and CD8+ T cells and lymph follicles (germinal centers)
28
Mouse dental formula
One incisor and 3 molars for each quadrant
29
Mating - hormonal changes
When vagina/cervix are stimulated, prolactin is released from the anterior pituitary to enable CL to secrete progesteron If fertilization has occured, placenta will take over production at 13 days
30
Milk production - mouse
Milk production increases up to 12 days post-partum and then declines until weaning at 21 days Majority of antibody is tranferred through colostrum .
31
Primary lymphoid tissues
Thymus and bone marrow
32
Secondary lymphoid tissues
Lymph nodes, spleen, and intestinal Peyer's patches
33
Tertiary Lymphoid tissues
Form in other solid organs in response to an insult or microbial exposure, e.g. - GALT, BALT
34
Innate immune system
Responds rapidly to antigen insult via recognition of PAMPs (LPS etc.) Monocytes/macrophages, granulocytes, and dendritic cells, innate-like lymphocyte populations (ILL) - NK cells
35
Adaptive immune system
T and B lymphocytes Highly antigen-specific receptor that has arisen through gene rearrangement
36
IgA
Serum IgA levels are low, but is the highest produced in mice Production occurs in plasma cells lodged in the laminal propria of mucosal tissues
37
Cytokines
Secreted signaling molecules involved in cell-cell communication interleukins, TNFs, interferons, GM-CSF Secretion occurs in response to recognition of antigen via PRR or TCR
38
Chemokines
Regulate cell-trafficking to sites of antigen encounter and facilitate cell-to-cell contact by acting as chemoattractants
39
Melanosis B6 mouse
heart valves, splenic capsule and trabeculae, meninges, cerebral vessels, Hardarian glands, and parathyroid
40
Paneth cells
Occupy crypt bases in the small intestines Specialized enterocytes have prominent eosinophilic cytoplasmic granules
41
Mouse rectum
Short (1-2mm), not enveloped in serosa Prone to rectal prolapse
42
Neonatal mouse bowel
Small intestinal enterocytes are vacuolated and may contain eosinophilic inclusions due to precense of apical-tubular system Very shallow crypts of Leiberkuhn Intestinal cell turnover kinetics are slow, making neonates highly suceptible to cytolytic viruses
43
Mouse placentation
Hemochorial
44
MHC
Chromosome 17 Causes rapid rejection of grafts that display foreign H2 antigens
45
Exorbital lacrimal gland
46
Exorbital lacrimal gland
47
Hardarian gland
48
Male submandibular salivary gland Columnar epithelium w/ basal nuclei
49
Female submandibular salivary gland Cuboidal epithelium w/ central nuclei
50
Male kidney - mouse
51
Female kidney - mouse
52
Hoover-Drichamer
Precense of urine from a foreign pregnant or lactating female prolongs estrus
53
Lee-Boot
When female mice are housed together in small groups (4-5) without a male present, there is an increase in the incidence of spontaneous pseudopregnancy
54
Vandenbergh
Accidental exposure of prepubescent female mice to male urine accelerates puberty

BB 3rd Edition (19 decks)

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