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NHP other viruses Flashcards

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1
Q

Adenoviruses

A 
Apes, OWM, NWM
Clinical disease respiratory or enteric
Necrotizing pancreatitis or hepatitis in immunocompromised macaques
Low mortality
INIB at villous tips
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2
Q

Simian virus 40/Polyoma virus

A

Common latent viral infection of Asian macaques
Isolated from rhesus kidney cells for polio vaccine
Oncogenic in hamsters
Clinical dz rare except in SIV, etc.
Dymyelination, chronic tubulointerstitial nephritis, proliferative interstitial pneumonia
INIB
Resembles progressive multifocal leukoencephalopathy in humans

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3
Q

Papillomavirus

A

Macaque and chimps
Dermal or oral lesions
Chimps: focal epithelial hyperplasia - multiple proliferative structures in oral mucosa
Macaques, baboons: cervical dysplasia, carcinomas

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4
Q

RPV

A

Rhesus parvovirus

INIB in erythroid precursors in bone marrow

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5
Q

Parvoviruses

A

Severe, normochromic, normocytic anemia

Cynos, rhesus, pig-tailed macaques (M. nemistrina)

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6
Q

Monkeypox hosts

A

AGMs, Macaques, apes, NWMs (captive)

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7
Q

Monkeypox in AGMs

A

High prevelance of antibodies, no clinical disease

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8
Q

Monkeypox in Apes

A

Viremia 3-4 days pi, fever, anxiety, aggression

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9
Q

Monkeypox in captive NWMs

A

Papules to vesicular rash with umbilication to classic pock lesion on buttocks, hands, and feet
Dissemination to lung, spleen, mms (hemorrhagic necrosis)
Not always fatal
ICIB

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10
Q

Monkeypox in humans

A

Fatigue, fever, headache, back pain, lymphandenopathy
Vesiculopapular rash all over body
Vaccination against smallpox provides immunity

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11
Q

Yaba virus

A

Poxvirus
Macaques, baboons
SQ masses of varying sizes on face, hands, feet
Oral masses in baboons
Nonencapsulated masses of large pleomorphic histiocytes +/- large ICIBs

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12
Q

Yaba virus in humans

A

Pseudotumors <2cm on hands and feet
Lymphadenopathy, fever
Regression
Poxvirus

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13
Q

Tanapox in humans

A

Poxvirus
Benign cutaneous skin infection
1-2 small papules on face, extremities, or trunk
Fever, headache, backpain

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14
Q

Tanapox in macaques

A

Poxvirus
Small red papules progressing to 1cm raised foci which become umbilicated
Resolve in 3-8 weeks
Epidermal proliferation and ballooning degeneration
INIB and ICIB

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15
Q

Marmoset poxvirus

A

Callithrix jacchus
Papulovesicular dz lasting 4-6 weeks
Not fatal

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16
Q

Molluscum contagiosum in humans

A

Mildly contagious chronic skin dz
Multiple small skin tumors filled with waxy material
Large central acanthocytes have ICIBs

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17
Q

Molluscum contagiosum in chimps

A

Small firm lesions with waxlike contents on face and inguinal area
Large ICIBs

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18
Q

Cowpox in C. jacchus

A

Disseminated fatal infection

ICIB, INIB

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19
Q

Adenovirus hosts

A

Apes, OWM, NWM

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20
Q

Simian Hemorrhagic Fever Virus

A

Arterivirus
Highly contagious and fatal
Asian macaques - bleeding diathesis

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21
Q

SHFV reservoir species

A

Patas, AGMs, baboons

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22
Q

SHFV distinguishing path feature

A

Hemorrhagic necrosis of proximal duodenum in macaques

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23
Q

Yellow fever in African monkeys

A

Vector = mosquito

Subclinical, short-lived viremia

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24
Q

Yellow fever in NWMs

A

Flavivirus
Severe, epizootic, fatal
Icterus, hepatic necrosis, hepatic fatty degeneration, Councilman and Torres bodies

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25
Yellow fever in humans
High fever, chills, headache, backache, myalgia prostration, nausea, vomiting, epistaxis, hematemesis, jaundice Death in 3-7 days pi
26
Kyasanur Forest dz vector
Ixodid tick
27
Kyasanur Forest dz - langurs
Pancytopenia, fever, bradycardia
28
Kyasanur Forest dz - Bonnet macaque
M. radiata | Epistaxis, GI hemorrhage, hepatocellular necrosis, hemorrhage, nonsupperative encephalitis
29
Kyasanur Forest dz - humans
Fever, chills, back pain, leg pain, headache, insomnia, anorexia, confusion, tremors Epistaxis, GI bleed, fatalities
30
Dengue
Flavivirus | Vector = mosquito
31
Dengue in macaques
No clinical dz
32
Dengue - Langurs
High incidence of antibody titers
33
Dengue - humans
Flavivirus Fever, headage, myalgia, rash, nausea, vomiting, hemorrhage, DIC, thrombocytopenia, shock Fulminant hepititis with encephalopathy
34
Marburg in humans
Filovirus Acquired from AGMs Fever, headache, tremors, joint aches, diarrhea, vomiting, epistaxis
35
Ebola Zaire Sudan in humans
Filovirus Unknown host Headache, fever, vomiting, myalgia, nausea, maculopapular rash, diarrhea, epistaxis, etc. 86% mortality
36
Cote d'Ivoire in humans
Filovirus | Dengue-like illness following chimp necropsy
37
Ebola Reston in cynos
Filovirus Anorexia, lethargy, hypothermia, nasal discharge, splenomegaly, facial petechia, severe SQ hemorrhages, depression, coma, death Can be zoonotic (no known human dz)
38
Ebola Reson reservoir host
Rousettus amplexicaudatus (Old world Fruit bat)
39
Ebola Reston characteristic lesions
Multifocal hepatocellular necrosis, multifocal necrosis within the zona glomerulosa of the adrenal gland, and mild interstitial pneumonia Distinguishes Reston from SHFV
40
Measles
Paramyxovirus Morbillivirus genus Infection can be subclinical or severe in macaques Induces immunosuppression
41
Measles vaccination
Vaccination with MLV successful = very important in marmosets! Interferes (immunosuppresive) with TB test leading to false negative - need 4-6 weeks to return to normal
42
Measles clinical signs in NWM
Skin, respiratory, GI, neurologic, abortion Koplic spot (tongue) Marmoset - GI dz with no rash, high mortality ICIB and INIB
43
Canine distemper virus
Paramyxovirus, Morbillivirus genus Rhesus, Japanese macaque (M. fuscata), cynos Respiratory, anorexia, pyrexia, thickening of foot pads, maculopapular rash, encephalitis
44
Paramyxovirus sanguinus
``` Paramyxovirus, genus Morbillivirus Callitrichids Anorexia, dehydration, diarrhea Necrotizing typhlocolitis Syncytia in crypts, pancreas, liver, kidney, and bile duct ICIB ```
45
Parainfluenza virus Type 1
Sendai, Paramyxovirus, Paramyxovirus genus Marmosets Sneezing, tachypnea, dyspnea, ocular/nasal discharge, depression, anorexia Low mortality, high morbidity
46
Parainfluenza virus Type 3
Simian agent 10, Paramyxovirus genus Patas, gibbons, chimps URI, predispose to Streptococcal infection
47
Respiratory Syncytial virus
Paramyxovirus, Pneumovirus genus Chimps URI
48
STLV
Simian T-cell lymphotropic virus Retrovirus Associated with lymphoproliferative dz in OWM, macaques, and humans Model for acute T-cell lymphoma (Baboons) Anorexia, depression, LN enlargement, hepatosplenomegaly Overt leukemia ~50% of cases
49
Simian type D retroviruses
SRVs | Simian betaretroviruses
50
Primary cause of immunodeficiency in captive macaques
SRV 1, 2, 4, and 5
51
Clinical syndromes of SRVs
1) persistant carrier, no clinical signs 2) Severe immunodeficiency and viremia 3) Clearance of infection 4) Retroperitoneal or subcutaneous firbromatosis nodules 5) Persistent lymphadenopathy
52
SRV-2
Simian betaretrovirus Associated with retroperitoneal fibromatosis Multinodular to coalescing mass originating from ileo-cecal junction Highly vascular with intersecting fascicles of spindle-shaped cells that infiltrate along serosal surfaces
53
SRV-1
Simian betaretrovirus Assocaited with SQ fibromatosis Multiple nodules in SQ and oral cavity Highly vascular with intersecting fascicles of spindle-shaped cells that infiltrate along serosal surfaces
54
SRV clinical signs
Progressive weight loss with diarrhea | Anemia, thrombocytopenia, neuropenia, lymphopenia, pancytopenia
55
SRV diagnosis
Serology is inadequate | Immunohistochemistry may be used to demonstrate RFHV latency-associated nuclear antigen (LANA)
56
SIV in African primate species
Subclinical
57
SIV in Asian primate species
AIDS-like
58
SIV
Lentivirus Closely related to HIV-1 and 2 Transmission to aberrant host = progressive loss of CD4 T cells and death w/i 18 months Seronegative, viral positive animals are rare Do not mix Asian and African species!
59
SIV opportunisitic infections
M. avium, CMV, adenovirus, SV40, Pneumocystis, Cryptococcus neoformans, noma, candida
60
SIV coinfection with RhLCV
Malignant B-cell lymphoma
61
Rabies
Tamarins, marmosets, squirrel monkeys, chimps, macaques | Irritability, self-mutilation, paralysis of pharyngeal and pelvis muscles
62
Rabies vaccination
Used of killed vaccine recommended | Used of attenuated virus associated with outbreak in NWM
63
LCMV
Viral hepatitis in Callitrichids From feeding wild rodents Hepatosplenomegaly, jaundice, SQ/IM hemorrhages, pleural/pericardial effusion Necrosis of liver, LN, adrenal glands, GI tract Elevated liver enzymes, bilirubin, and ALKP Zoonotic
64
Hepatitis A
Chimps, cynos, AGMs, owl monkeys Fecal-oral transmission Elevated ALT and AST 2-10x normal, elevated bilirubin Usually self-limiting Focal hepatocellular necrosis with nonsuppurative inflammatory infiltrates in portal area Zoonotic
65
Encephalomyocarditis virus
``` Picornavirus Fatal infection in owl and squirrel monkeys, baboons, rhesus, chimps Wild rats are reservoir Death with no c/s NONSUPPURATIVE NECROTIZING MYOCARDITIS ```
66
Poliovirus
Great apes, rhesus No c/s or paresis/parapegia and death Lesions in grey matter of CNS Vacciation of apes recommended with trivalent oral polio vax

BB 3rd Edition (19 decks)

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