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BB 3rd Edition > Bacteria > Flashcards

Bacteria Flashcards

(46 cards)

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1
Q

L. intracellularis

A

Obligate intracellular, proliferative enteritis

Not encountered in research colonies

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2
Q

Mycoplasmosis

A

M. pulmonis, M. arthritidis, M. neurolyticum, M. collis, and M. muris

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3
Q

M. pulmonis

A

Gram negative

Murine respiratory mycoplasmosis

Suppurative rhinitis, otitis media, chronic pneumonia - CHATTERING, head tilt

Can be transmitted aerosol, venerally, transplacental (rats)

Rats are only significant resevoir for mice

Serology may not detect difference between M. pulmonis/M. arthritidis

Athymic mice not more susceptible (T-cell response exacerbates)

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4
Q

M. pulmonis - pathology

A

Colonizes apical surface of respiratory epithelium

Extracellular

B6 resistant, BALB/c, C3H, SJL, CBA, AKR, SWR, DBA/2 varying degrees of increased susceptibility

Inital lesions is suppurative rhinitis ->squamous metaplasia, syncytia sometimes

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5
Q
A

M. pulmonis rhinitis

Turbinate mucosa contains accumulations of plasma cells and lymphocytes, epithelial is decreased in thickeness and has lost most cilia, lumen contains neutrophilic exudate

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6
Q
A

M. pulmonis

Bronchiolitis and bronchiolectasis

Bronchioles are dilated, contain neutrophilic exudate and are surrounded by accumulations of plasma cells and lymphocytes. Mucosa is infiltrated with inflammatory cells

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9
Q

M. arthritidis

A

Antigentically related to M. pulmonis, nonpathogenic during natural infection

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10
Q

M. neurolyticum

A

Rolling disease

usually die within 4 hours

Experimental innculation with exotoxin

Astrocytic swelling

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11
Q
A

CAR bacillus induced bronchiolitis and pneumonia in mouse. Bronchiole is surrounded by lymphocytes, the lumen contains neutrophilic exudate, and the epithelium is hyperplastic. Adjacent alveoli contain neutrophils and macrophages

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12
Q
A

CAR bacillus induced rhinitis in a mouse

Epithelium is infiltrated by neutrophils and lymphocytes and the underlying tissue is hyperplastic. Basophilic CAR bacilli are visible among the cillia at the left

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13
Q

Hemotropic mycoplasmas

A

Mycoplasma hemomuris and Mycoplasma coccoides

Tropic for RBCs, anemia, hemolytic disease

Splenomegaly

Either acute febrile anemia or latent/subclinical infection that can be reactived by splenectomy/irradiation

Vector: Polyplax serrata (mouse louse)

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14
Q
A

Tranmissible Murine Colonic Hyperplasia

Descending colon is thickened and opaque

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15
Q

CAR Bacillus

A

Gram negative, non-spore forming

Produces clinical disease in rats

Transmitted through direct contact

Peribronchiole cuffing with lymphocytes and plasma cells

Warthin-Starry

tx: sulfamerazine

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16
Q
A

Colonic inflammation, edema, mild hyperplasia of the epithelium, and significant development of mucosa-associated lymphoid tissue (MALT) caused by C. rodentium

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19
Q
A

Multiple abscesses in a nude mouse caused by P. pneumotropica

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20
Q

Transmissible Murine Colonic Hyperplasia

A

C. rodentium, gram negative

Self-limiting to severe colitis

Retarded growth, ruffled fur, soft feces or diarrhea, rectal prolapse, and moderate mortality in older suckling or recently weaned

Contaminated mice, food, bedding

Model EPEC/EHEC

DBA, NIH/Swiss, C57BL resistent, C3H susceptible

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21
Q
A

Electron micrograph of H. hepaticus in hepatic bile canaliculi

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23
Q
A

H. bilis induce non suppurative hepatitis and hepatic necrosis. Inflammation originates in portal triads

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24
Q

TMCH - pathology

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A

Attaches to mucosa of descending colon and displaces normal flora

Attaching and effacement lesions

Lasts 2-3 weeks in surviving animals

Can be cultured on MacConkey’s during early stages only

26
Q

Psuedomoniasis

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A

Pseudomonas aeruginosa, gram negative rod

Immunodeficient animals can be prone to septicemia

Equilibrium disturbances, conjunctivitis, serosanguinous nasal discharge, edema of the head, weight loss, skin infections, torticollis

Acidification/hyperchlorination of water
Antibiotic and quat resistant

27
Q

P. pneumotropica

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A

Gram negative

Usually subclinical, opportunistic pathogen

Suppurative lesions - preputial and orbital abscesses

Does not transmit from infected mice to contact/bedding sentinels

Tx: enrofloxacin

29
Q

Helicobacter hepaticus

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A

Chronic active hepatitis, hepatic tumors, IBD

Colonizes crypts of lower bowels

31
Q

Helicobacters - mice

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A

hepaticus, bilis (rats also), rodentium, ganmani, mastromyrinus, magdeburgensis, typhlonius

33
Q

H. bilis

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A

Isolated from livers and intestines of aged mice and experimentally induces IBD in SCID

34
H. muridarum
Colonizes ileum, cecum, and colon Nonpathogenic
35
Helicobacter treatment
Amoxicillin, metro, and bismuth - H. hepaticus
36
Salmonellosis
S. enterica subsp. enteria serovar Typhimurium and serovar Enteritidis Antimicrobial resistance genes, type III secretion systems, Vi antigen, LPS PAMPs interact with TLRs/NOD-like receptors leading to inflammasome formation and release of pro-inflammatory cytokines Acute infection severe in young mice - anorexia, weight loss, dull hair coat, lethargy, humped posture, conjunctivitis Ingestion of contaminated products, subclinical carriers/shedders ZOONOTIC
37
S. enteritidis
Reach Peyer's patches w/i 12h after innoculation -\> mesenteric lymph nodes Persists in spleen, liver, lymphnodes, gall bladder Chronic arthritis Visceral hyperemia, pale livers, catarrhal enteritis, acute death Spleen/liver - yellow/pale foci of necrosis Granulomatous lesions - characteristic of chronic salmonellosis
38
Culture for salmonella
Selenite F broth plys cystine followed by streaking on brillant green agar Feces, mesenteric lymph node
39
Streptobacillosis
Streptobacillus moniliformis, gram negative Can exist as a nonpathogenic L-phase varient in vivo or can revert to virulent bacillus form Acute phase - high mortality, subacute phase, chronic phase Dull, damp hair coat and keratoconjunctivitis Anemia, diarrhea, hemoglobinuria, cyanosis, emaciation, hindlimb paralysis, cutaneous ulceration, athritis, gangrenous amputation, urinary bladder distension, stillbirths, abortions ZOONOTIC - Haverhill (rat bite) fever
40
S. moniliformis
Necrotic lesions in thoracic and abdominal viscera, septic thrombi, fibrin Chronic - purulent polyarthritis
41
C. piliforme in liver
42
C. kutscheri
Pseudotuberculosis in mice and rats, often subclinical, inappetence, emaciation, rough hair coat, hunched posture, hyperpnea, nasal and ocular discharge, cutnaeous ulceration, arthritis Gray-white nodules on liver, kidney, lung, cervical lymphadenopathy and arthritis Coagulative/caseous necrosis with intense neutrophilic infiltration "Chinese letters"
43
Staphylococcosis
Most common - S. aureus (highly pathogenic) and S. epidermidis (nonpathogenic) Pathogenic Strep generally coagulase positive (except S. xylosus) Suppurative conjunctivitis, orbital abscesses, preputial adenitis, pyoderma B6, C3H, DBA, BALB/c mice most susceptible
44
Streptococcosis
Pathogenic streptococcal infeciton are caused by Beta-hemolytic in Lancefield's group C Group D - Enterococcus Cutaneous infection, conjunctivitis, rough hair coat, hyperpnea, somnolescence, and emacitation
45
Colibacillosis
Hyperplastic typhlocolitis has been reported in SCID mice Lethargy, fecal staining
46
Klebsiella pneumoniae
Gram-negative Opportunistic pathogen AAHC in humans, model with Clavamox Utero-ovarian infections in aged B6C3F1 Tilivalline - cytotoxin
47
C. difficile
Antimicrobial-associated pseudomembranous colitis Also in GPs, rabbits, Syrian hamsters, prarie dogs, ostriches, and horses Cycloserine-cefoxitin-fructose agar for culture Nonhemolytic, gray, umbonate profile with filamentous edges and ground glass appearance Toxins A and B Rapidly germinate and established infeciton
48
C. perfringens
Double zone of hemolysis, gray, smooth, round Five types based on four major toxins - major is enterotoxin Ingestion of spores Type A - part of normal microbiota Type D - report of mortality in 2-3 week old mice Tx: chlortetracycline Hcl, Penicillin G
49
C. piliforme
Tyzzer's, first described in Japanese Waltzing mice Gram negative Unexpected deaths, diarrhea, inactivity, high mortality Stress B6 more resistant, DBA/2 more susceptible (B cell function) Cross-infection - mice, rats, hamsters Spore can retain infectivity at room temp for at least 1 year
50
C. piliforme - pathology
Begins in GI -\> liver, heart Necrosis (above and MLNs) Ileum, cecu, colon, may be red and dilated, watery, fetid contents Liver, MLN, heart - gray-white foci Necrosis of mucosal epithelium, liver - coag necrosis along portal vein Silver stains, Giemsa, or PAS are required for visualization
52
Mycobacteriosis
M. avium-intracellulare and M. lepraemurium Chronic granulomatous disease, Langhans giant cells, acid-fast bacteria M. lepraemurium may cause alopecia, thickening of skin, SQ swellings, ulceration Hallmark is perivascular granulomatosis with accumulation of large, foamy epitheloid macrophages (lepra cells) packed with acid-fast bacilli
53
Proteus mirabilis
Ubiquitous gram-neg, can remain latent in the resp and intestinal tracts of mice Commonly found in lab mice Ass. with ulcerative lesions in Gi of immunodeficient mice (lose weight, diarrhea, die, septicemia) Pyelonephritis - abscessation and scarring Splenomegaly and focal necrotizing hepatitis - immunodeficient
54
Leptospirosis
One of the most common zoonoses transmissible from rodents, but very rate in lab mice L. interrogans serovar ballum (zoonotic) Gram negative, establish infection in renal tubules Subclinical
55
Chlamydia infection
C. trachomatis (intracellular) - produces glycogen-positive intracytoplasmic inclusions (elementary bodies) Ocular and urogenital disease in humans C. psitaci
56
Chlamydia muridarum
"Nigg agent" - C. muridarum - experimental model of human chlamydia Also known as "mouse pneumonitis agent" Severe, acute infection, ruffled fur, hunched posture, labored respiration due to interstitial pneumonitis and death Cyanosis of ears and tail Dx: impression smears stained with Giemsa/Macchiavello stains

BB 3rd Edition (19 decks)

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