MSK Flashcards
NSAIDs e.g. ibuprofen & naproxen
-indication
- Pain relief in MSK disorders
- Post op analgesia
- fever in children
NSAIDs
-Mode of action
Reversible inactivation of COX enzyme thus causing suppression of prostaglandins
NSAIDs
-side effects
- GI haemorrhage
- Hypertension
- Heart failure
- AKI
- Asthma
- Increased risk of CV events
Paracetamol
-indication
Mild to moderate pain
Pyrexia
Paracetamol
-Mode of action
COX inhibitor but minimal anti-inflammatory effect
Paracetamol
-side effects
Hepatotoxicity
Allopurinol
-indication
- Prophylaxis of gout
- Prophylaxis of renal stones
- Prophylaxis of post-chemotherapy hyperuricaemia
Allopurinol
-Mode of action
Reduces uric acid synthesis through inhibition of xanthine oxidase
Allopurinol
-side effects
- Risk of azothioprine toxicity with concurrent use
- Rash (withdrawal therapy if occurs due to risk of SJS/TEN)
Colchicine
- Indication
- Rx of acute gout
- Short -term prophylaxis of gout during initiation of allopurinol
- Treatment of Familial Mediterranean Syndrome
Methotrexate
- Indication
- DMARD in rheumatoid disorders
- Crohn’s disease
- Oncology
Methotrexate
- Mode of action
Immunomodulator preventing the formation of tetrahydrofolate
(Patients on methotrexate should also receive: Folate 5 mg once weekly, dose to be taken on a different day to methotrexate dose)
Colchicine
- Mode of action
Prevents neutrophil activation, migration and degranulation
Colchicine
- Side effects
GI distrubance (diarrhoea)
“You have to get the runs before you can walk”
Methotrexate
- Side effects
- Bone marrow suppression
- Hepatotoxicity
- Pulmonary toxicity
Note: administered weekly
Note: plasma concentration is increased by the use of NSAIDs -> toxicity risk
