MTX Flashcards
1
Q
MTX affects proliferation of lymphocytes and blocks migration of activated T cells into certain tissues
A
T
2
Q
Anti inflammatory effects in MTX ARE mediated by adenosine
A
T
3
Q
Risk factors for hepatotoxicity in MTX
A
Renal insufficiency
Obesity
DM
Excessive alcohol consumption
4
Q
MTX is metabolized intracellularly
A
T
5
Q
MTX inhibits pyrimidine formation
A
T
6
Q
MTX suppresses primary and secondary antibody responses and no effect on delayed type hypersensitivity
A
T
7
Q
MTX affected proliferation of keratinocytes in psoriasis
A
False
Most likely acts through immunosuppressive mechanism
8
Q
Inhibits methionine synthetase leading to reduced S-adenyl methionine - anti inflammatory effects
A
T
9
Q
MTX inhibits chemotaxis by PMNs and blocks inflammation induced by C5a
A
T
