Systemic Corticosteroids Flashcards
(27 cards)
Systemic corticosteroids increase secretion of gonadotropins and increase levels of testosterone in men and estrogen in women
False
Reduce
Systemic corticosteroids inhibit osteoprotegerin (osteoclastogenesis inhibitory factor)
T
Systemic corticosteroids promote bone loss by reducing calcium absorption and increasing renal calcium excretion
T
All endogenous and synthetic CS are well distributed into fetal tissue with exception of prednisone
T
The main carrier protein for CS is albumin
F
Cortisol binding globulin
CBG is decreased by hypothyroidism, liver disease, renal disease and obesity , increasing free fraction of CS
T
Exogenous CS is absorbed in the upper duodenum
F
Upper Jejunum
Prednisolone is preferable to prednisone in severe liver disease
T
Active form of cortisol is hydrocortisone
T
Hydrocortisone is formed through hepatic conversion of 11-ketone to 11-hydroxyl group by 11b hydroxysteroid dehydrogenase
T
In top steroids the MC effect is decreases by masking of the 16- or the 17- hydroxyl group with various ester links
Eg vale rate
Acetonide
Diproprionate
T
CS causes eosinophil and lymphocyte apoptosis
T
Cellular immunity > humoral immunity in CS
T
All endogenous and synthetic CS are well distributed into fetal tissue with exception of prednisone
T
The main carrier protein for CS is albumin
F
Cortisol binding globulin
CBG is decreased by hypothyroidism, liver disease, renal disease and obesity , increasing free fraction of CS
T
Exogenous CS is absorbed in the upper duodenum
F
Upper Jejunum
Prednisolone is preferable to prednisone in severe liver disease
T
Active form of cortisol is hydrocortisone
T
Hydrocortisone is formed through hepatic conversion of 11-ketone to 11-hydroxyl group by 11b hydroxysteroid dehydrogenase
T
In top steroids the MC effect is decreases by masking of the 16- or the 17- hydroxyl group with various ester links
Eg vale rate
Acetonide
Diproprionate
T
CS causes eosinophil and lymphocyte apoptosis
T
Cellular immunity > humoral immunity in CS
T
Addition of fluorine to hydrocortisone at 9a position leads to increased GC and decreased MC activity
F
Excessive MC ACTIVITY
