Topicsl Calcineurin Inh Flashcards
1
Q
Tacrolimus binds to calcineurin
A
F
Binds to FK506 a rotamase enzyme
Complex then binds to calcineurin
2
Q
Tacrolimus prevents transcription of genes encoding IL-2
A
True
3
Q
Tacro is effective in AA, FFA and haemodialysis related pruritis
A
False
Ineffective
4
Q
Tacro absorption is low in atopic dermatitis but marked in nethertons syndrome
A
T
5
Q
Tacrolimus is a macrolides produced by the soil bacterium streptomyces tsukubaensis
A
True
6
Q
Pimecrolimus may act by reducing NFAT-2 activity in follicular keratinocytes
A
T
7
Q
Children under 2 and active skin infection at site of tx are absolute CI for top CN inh
A
F
Relative
8
Q
Pimecrolimys is effective in AA and Acne
O
A
F
