Flashcards in Muscle 3 Deck (15):
1
What is IL-15?
Myokine released during muscle contractions
2
What does IL-15 do?
Increases muscle glucose uptake and lowers the rate of contractile protein deterioration
3
What are the benefits of IL-15?
Increases myoblast differentiation, decreases protein degradation, increases protein synthesis
4
What does IL-15 do to the diaphragm?
Increasing force producing capacity and preserves musculature
5
What is poloxamer-188?
Synthetic, non ionic, nontoxic block copolymer surfactant
6
What does poloxamer-188 do?
Plugs holes in torn membranes to prevent muscle damage and boost repair
7
What are heat shock proteins?
Molecular chaperones involved in protein folding
8
When are heat shock proteins released?
In response to stress
9
What happens to SERCA at high temps when Hsp70 is absent?
Reduced activity
10
What happens when Hsp70 is overexpressed?
Amelioration of dystrophic pathophysiology
11
What does BGP-15 do?
Improves SERCA activity, pathology, calcium uptake and survival (24%)
12
What muscle did BGP-15 reduce fibrosis in?
Tibialis anterior
13
Does BGP-15 have an affect in older mice?
No improved muscle function
14
What is tranilast?
Orally bioavailable anti-allergic approved for human use
15