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FRONTIERS IN PHYSIOLOGY > Muscle 3 > Flashcards

Flashcards in Muscle 3 Deck (15):
1

What is IL-15?

Myokine released during muscle contractions

2

What does IL-15 do?

Increases muscle glucose uptake and lowers the rate of contractile protein deterioration

3

What are the benefits of IL-15?

Increases myoblast differentiation, decreases protein degradation, increases protein synthesis

4

What does IL-15 do to the diaphragm?

Increasing force producing capacity and preserves musculature

5

What is poloxamer-188?

Synthetic, non ionic, nontoxic block copolymer surfactant

6

What does poloxamer-188 do?

Plugs holes in torn membranes to prevent muscle damage and boost repair

7

What are heat shock proteins?

Molecular chaperones involved in protein folding

8

When are heat shock proteins released?

In response to stress

9

What happens to SERCA at high temps when Hsp70 is absent?

Reduced activity

10

What happens when Hsp70 is overexpressed?

Amelioration of dystrophic pathophysiology

11

What does BGP-15 do?

Improves SERCA activity, pathology, calcium uptake and survival (24%)

12

What muscle did BGP-15 reduce fibrosis in?

Tibialis anterior

13

Does BGP-15 have an affect in older mice?

No improved muscle function

14

What is tranilast?

Orally bioavailable anti-allergic approved for human use

15

What does tranilast do?

Decreased fibrosis 31% in diaphragm of mdx mice but this did not translate to improve specific force