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Flashcards in Muscle Deck (29):
1

Epimyusium

covers entire muscle

2

perimysium

covers muscle fasicle

3

endomysium

covers each muscle cell

4

A bands
I bands

a bands dark
i bands light

5

actin vs myosin

thin -actin part of the I band
thick myosin part of the a band

6

titin

associated with myosin
during relaxation titin generates passive tension

7

Desmin

intermediate filament
encircles z disk of each sarcomere
attaches to costameres (special sarcolemma)

8

Muscle contraction what shortens what stays the same

The H and I band reduce
A and Z stay the same

9

What is the back up source of energy during muscle contraction?

hydrolysis of creatine phosphate

10

what would an antibody against the voltage gated K channel

lasting depolarzation state following release of neurotransmitter

11

Antibody to voltage gated CA 21 channel

continous inflow of Ca causing muscular weakness

12

Botulinum toxin

prevents release of acetylcholine
binds to presynaptic memebrane

13

Curare

binds to acetylcholine receptor
prevents binding of acetylcholine
paralysis

14

Myasthenia gravis

autoantibody binding to the acetylcholine receptor causes myasthenia gravis (fatigue with exercise)

15

Muscle Contraction

1. action potential along sarcolemma reaches t tubule
2. depolarization
3. l type voltage sensitive calcium channel (membrane transverse tubule) changes conformation
4. conformationc hange induces ryanodine sensitive calcium channel in membrane of sarplasmic reticulum release calcium
3. ryanodine sensitive ca channel opens and release calcium

16

calsequestrin

binds calcium in the lumen of sarcoplamic reticulum

17

ca-atpase

mediates return of calicum to the sarcoplasmic lumen

18

Satellite cells

stem cell population
for stres or trauma

19

What is in the longitudinal component of the intercalated disk

gap juntion

20

what is in the transverse component of the intercalated disk

desmosomes and fascia adherentes

21

phospholamban

controls active transport of calcium into the lumen of the sarcoplasmic reticulum

22

Where are triads seen?

skeletal muscle

23

where are diads seen?

cardiac muscle

24

at what levels are diads found?

at the level of the z disc

25

at what levels are triads found?

at the level of the a/ I junction

26

Cardiac muscles have what type of nuclues

central located

27

Mycardial ischeemia

occlusion of the coronary artery results within the first 24 hours
pyknotic (irregulary shaped nucleus)

28

caveolae

depressions of plasma memebrane
fluid and electrolyte transport (pinocytosis)

29

red muscle fibers versus white

red-jogging mitocondria
white-sprinting